angiotensin receptor blocker
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angiotensin receptor blocker (ARB),
agent that binds with angiotensin receptors, thus preventing access of angiotensin II to the receptor and consequently reducing the vasoconstriction produced by this agonist; used in the treatment of hypertension.
Farlex Partner Medical Dictionary © Farlex 2012
angiotensin II receptor antagonist
Any of a family of agents (e.g., losartan and valsartan) that block the binding of angiotensin II (A-II) to their cognate cell receptors—AT1, AT2 and others. First-generation ARAs included the sartan family of agents, which only block AT1, interacting with the amino acids in the transmembrane domains to block the binding of A-II to AT1.ARAs are an alternative to ACEI therapy in patients with CHF; unlike ACEIs, ARAs do not interfere with bradykinin and prostaglandin metabolism, interference of which has been linked to some of the adverse effects of ACEI therapy, particularly to cough and angioedema.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
an·gi·o·ten·sin re·cep·tor block·er
(an'jē-ō-ten'sin rĕ-sep'tŏr blok'ĕr)An agent (e.g., losartan) that binds with angiotensin receptors, thus preventing access of angiotensin II to the receptor and consequently reducing the vasoconstriction produced by this agonist; used in the treatment of hypertension.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012