angiotensin IV

angiotensin IV

A hexapeptide derived from angiotensin III after it angiotensinases the N-terminal arginine. Angiotensin IV has some pressor and aldosterone-producing activity.
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Harding and College of Arts and Sciences Professor Jay Wright, have been working on their compound since 1992, when they started looking at the impact of the peptide angiotensin IV on the hippocampus, a brain region involved in spatial learning and short-term memory.
Typically, angiotensins have been linked to blood pressure regulation, but Harding and Wright noticed that angiotensin IV, or early drug candidates based on it, were capable of reversing learning deficits seen in many models of dementia.
Angiotensin 11 and its hexapeptide metabolite, angiotensin IV, have been shown to increase levels of the circulating plasminogen-activator inhibitor (PAI)-1, known to promote thrombosis as well as inhibit the body's natural thrombolytic agent, tissue plasminogen activator (tPA).
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