Racine-Poon, An Interaction Study with Cimetidine and the New Angiotensin II Antagonist
Antihypertensive medicines dispensed for free during SNP were: (i) beta-blocking agents: atenolol 25 mg and propranolol hydrochloride 40 mg; (ii) diuretics: hydrochlorothiazide 25 mg; and (iii) agents acting on the renin-angiotensin system inhibitors (Class C09 on European Pharmaceutical Marketing Research Association (EphMRA) Anatomical Classification) including (a) the angiotensin-converting-enzyme (ACE) inhibitors captopril 25 mg and enalapril maleate 10 mg; and (b) the angiotensin II antagonist
or angiotensin receptor blocker (ARB) losartan potassium 50 mg (10).
Fischer, "Effects of angiotensin II and angiotensin II antagonist
saralasin on cell growth and renin in 3T3 and SV3T3 cells," Journal of Cellular Physiology, vol.
Arakawa, "Angiotensin II antagonist
prevents electrical remodeling in atrial fibrillation," Circulation, vol.
Post hoc analyses from the Reduction of Endpoints in NIDDM (non-insulin-dependent diabetes mellitus) with the Angiotensin II Antagonist
Losartan Study (RENAAL) trial in patients with diabetes illustrated that each 50% reduction in albuminuria induced by treatment with an angiotensin-receptor blocker (ARB) during the first months of therapy was associated with 45% and 18% risk reduction for renal and CV events, respectively, during the ensuing 3.4 years of follow-up (Table 1 and Fig.
The ANTIPAF (Angiotensin II Antagonist
in Paroxysmal Atrial Fibrillation) trial involved a total of 425 patients at 37 participating German centers.
(5) The Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist
Losartan (RENAAL) study in which patients with T2DM and nephropathy were randomised to losartan or placebo in addition to conventional treatment reported a 16% risk reduction (p=0.02) of primary outcome in patients treated with losartan compared with the placebo group.
The Heart Failure Endpoint Evaluation of Angiotensin II Antagonist
Losartan (HEAAL) trial enrolled patients with symptomatic, New York Heart Association class II-IV heart failure who had a left ventricular ejection fraction of 40% or less.
The principle active valsartan is a nonpeptide, orally active and specific angiotensin II antagonist
acting on the [AT.sub.1] receptor subtype.
Findings from the Irbesartan Diabetic Nephropathy Trial (IDNT) and the Reduction of Endpoints in NIDDM with Angiotensin II Antagonist
Losartan (RENAAL) indicate that ARBs are more effective than other agents in slowing the progression of kidney disease in patients with macroalbuminuria due to type 2 diabetes.
Optimal Trial in Myocardial Infarction with Angiotensin II Antagonist
COZAAR is the world's most widely prescribed medication in the angiotensin II antagonist
class and it continues its strong growth, as physicians increasingly recognize the excellent tolerability and efficacy of these two products.