angiotensin II


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an·gi·o·ten·sin II

(an'jē-ō-ten'sin),
A vasoactive octapeptide produced by the action of angiotensin-converting enzyme on angiotensin I; produces stimulation of vascular smooth muscle, promotes aldosterone production, and stimulates the sympathetic nervous system.

angiotensin II

An octapeptide derived from angiotensin I after angiotensin-converting enzyme acts on angiotensin I, cleaving the C-terminal dipeptide. Angiotensin II is a potent vasoconstrictor (4- to 8-fold more potent that norepinephrine) and has a very short (1–2 minutes) T1⁄2 in the circulation; it induces arteriolar constriction and increases systolic and diastolic blood pressure. Angiotensin II acts directly on the adrenal cortex, increasing aldosterone secretion, facilitating norepinephrine release by direct action on the post-ganglionic sympathetic neurons. It acts on the brain, increasing water intake, vasopressin and ACTH secretion.

an·gi·o·ten·sin II

(an'jē-ō-ten'sin)
A vasoactive octapeptide produced by the action of angiotensin-converting enzyme on angiotensin I; produces stimulation of vascular smooth muscle, promotes aldosterone production, and stimulates the sympathetic nervous system.
References in periodicals archive ?
Angiotensin II stimulates endothelial cell adhesion molecule I via nuclear factor [kappa][beta] activation induced by intracellular oxidative stress.
Haplotypes of the angiotensin II receptor genes AGTR1 and AGTR2 in women with normotensive pregnancy and women with preeclampsia.
Kawai et al., "Vascular ADAM17 as a novel therapeutic target in mediating cardiovascular hypertrophy and perivascular fibrosis induced by angiotensin II," Hypertension, vol.
Rockman, "Dual inhibition of beta-adrenergic and angiotensin II receptors by a single antagonist: a functional role for receptor-receptor interaction in vivo," Circulation, vol.
Data were presented as mean [+ or -] SD (baseline characteristics) or SEM (plasma and tissue angiotensin II and angiotensin 1~7 concentrations and gene expressions).
The present case with motor impairment and failure to thrive at age 26 months underlines the importance of consistent interdisciplinary monitoring of all patients having been exposed to angiotensin II receptor antagonists during the fetal period, especially focusing on long-term neurodevelopmental outcome.
Jamali, High-Performance Liquid Chromatographic Analysis of Angiotensin II Receptor Antagonist Valsartan Using a Liquid Extraction Method, J.Chromatogr.B., 766, 345 (2002).
Faix (2006).Gestational therapy with an angiotensin II receptor antagonist and transient renalfeature in premature infant.
3-NT: 3-Nitrotyrosine 4-HNE: 4-Hydroxynonenal Actin: B-Actin Ang II: Angiotensin II ATF4: Activating transcription factor 4 Bax: Bd-2-associated X protein Bcl-2: B-cell lymphoma 2 BIP: Binding immunoglobulin protein CHOP: C/EBP homologous protein DTT: Dithiothreitol ER: Endoplasmic reticulum HO1: Heme oxygenase 1 IL-6: Interleukin 6 NRF2: Nuclear factor (erythroid-derived 2)-like 2 NQO1: NAD(P)H dehydrogenase (quinone 1) SFN: Sulforaphane TNF-[alpha]: Tumor necrosis factor-[alpha] VCAM-1: Vascular cell adhesion molecule-1 WT: Wild type.
Fromter, "An electrophysiological study of angiotensin II regulation of Na-HCO3 cotransport and K conductance in renal proximal tubules--I.

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