angiotensin I


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Related to angiotensin I: angiotensin II

an·gi·o·ten·sin I

(an'jē-ō-ten'sin),
A decapeptide of slightly variable sequence, depending on the animal source, formed from the tetradecapeptide angiotensinogen by the removal of four amino acid residues, a reaction catalyzed by renin; a peptidase cleaves off a dipeptide (histidylleucine) to yield angiotensin II, the physiologically active form.

angiotensin I

An N-terminal decapeptide produced when renin acts on angiotensinogen. Angiotensin I is the precursor of angiotensin II but itself has no known physiologic role.

angiotensin I

An N-terminal decapeptide produced when renin acts on angiotensinogen; A-I is the precursor of angiotensin II, but itself has no known physiologic role. See Angiotensinogen.
References in periodicals archive ?
Harbeson et al., "Angiotensin i is largely converted to angiotensin (1-7) and angiotensin (2-10) by isolated rat glomeruli," Hypertension, vol.
(68) Renin snips off a small portion of the angiotensinogen molecule, producing a short amino acid chain called angiotensin I. (5) Another enzyme, angiotensin-converting enzyme (ACE), then makes one final snip to produce the active peptide hormone angiotensin II.
These drugs prevent that final step in which angiotensin I is converted to active angiotensin II.
Angiotensin I produced Endogenous after an incubation of angiotensin I 1 h at 37 [degrees] C Sample 1 Mean (SD), [micro]/L/h 0.69 (0.14) 0.06 (0.05) CV, % 20.1 84.2 Sample 2 Mean (SD), [micro]/L/h 0.88 (0.12) 0.14 (0.03) CV, % 14.1 22.3 PRA result Sample 1 Mean (SD), [micro]/L/h 0.63 (0.15) CV, % 23.7 Sample 2 Mean (SD), [micro]/L/h 0.73 (0.10) CV, % 13.5
The angiotensin I converting enzyme (ACE-EC 3.4.15.1) is a widespread zinc-metallopeptidase that converts angiotensin I (AI) to the vasoconstrictor octapeptide angiotensin II (AII).
Inhibition of angiotensin-converting enzyme by quercetin alters the vascular response to bradykinin and angiotensin I. Pharmacol 65, 182-186.
"The present data suggest that angiotensin I receptor blockade improves glucose metabolism at the cellular level, beyond what can be expected by the vasodilatation and blood pressure reduction alone," said Dr.
In vitro renin inhibition to prevent generation of angiotensins during determination of angiotensin I and II.
* elucidation of the amino acid composition and sequence of hypertension II and its biochemical relationship to angiotensin I;
The findings are "consistent with the concept that angiotensin is involved in contributing to the progression of heart failure and by blocking angiotensin with valsartan, we slowed progression," said Dr.
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