angiostatin


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Related to angiostatin: endostatin

an·gi·o·sta·tin

(an-jē'ō-sta-tin),
Antiangiogenesis factor produced by some tumors, a 38-kD product of proteolytic plasminogen breakdown.
[angio- + G. statos, stalled, standing still, + -in]

angiostatin

(ăn′jē-ō-stăt′n)
n.
A naturally occurring protein that is a specific inhibitor of endothelial proliferation and a potent angiogenesis inhibitor. It is under investigation as a potential cancer therapy.

angiostatin

(an″jē-ō-stat′ĭn) [ angio- + statin]
A protein fragment of plasminogen that inhibits the growth of blood vessels, possibly by blocking the enzyme ATP synthase on the endothelium. It may shrink malignant tumors by decreasing their blood supply.

angiostatin

A degradation product of PLASMINOGEN that interferes with the development of blood vessels (angiogenesis) and offers promise as an anticancer agent. Growth of tumours beyond about 3 cu. mm. depends on the development of a good blood supply by the growth of small blood vessels. This applies both to the primary tumour and to any remote deposits (mestastases) of spread cancer. Trials have shown that angiostatin can cause early tumours to die from lack of a blood supply. See also ENDOSTATIN.
References in periodicals archive ?
Angiostatin is released by MMP2, MMP3, MMP7, MMP9, MMP12, MMP13 and MMP20 [20].
Angiostatin diminishes activation of the mitogen-activated protein kinases ERK-1 and ERK-2 in human dermal microvascular endothelial cells.
The effect of angiostatin on vascular leakage and VEGF expression in rat retina.
Angiostatin and matrix metalloprotease expression following ischemic acute renal failure.
Angiostatin showed encouraging results in which its ability to shrink primary tumors and inhibit vascularization as well as metastatic colony development were confirmed both through in vitro and animal models.
The article concerned two new agents, endostatin and angiostatin, developed by Harvard Professor judah Folkman, MD.
Some inhibitors are platelet and plasma-derived such as angiostatin, endostatin, and platelet factor-4 (Daly et al.
Generation of biologically active angiostatin kringle 1-3 by activated human neutrophils.
Two proteins, angiostatin and endostatin, have been shown to possess anti-angiogenic activity.
MMP-9 can generate angiostatin via an interaction with plasminogen, increase its affinity for collagen, interact with intercellular adhesion molecule-1, and be antiinflammatory by processing interleukin (IL)-1(3 from its precursor and by reducing IL-2 response.
For example, Judah Folkman first envisioned the idea of angiogenesis at the beginning of his career, more than forty years ago, yet neither endostatin nor angiostatin, the potent antiangiogenesis drugs he developed, nor others in this category that have been developed by other researchers, had been approved by the Food and Drug Administration in mid-2004.
Although many synthetic and exogenous inhibitors of angiogenesis have been developed, the inhibitors that have received the most attention are the naturally derived endogenous proteins angiostatin and endostatin.