angiostatin


Also found in: Dictionary, Wikipedia.
Related to angiostatin: endostatin

an·gi·o·sta·tin

(an-jē'ō-sta-tin),
Antiangiogenesis factor produced by some tumors, a 38-kD product of proteolytic plasminogen breakdown.
[angio- + G. statos, stalled, standing still, + -in]

angiostatin

(ăn′jē-ō-stăt′n)
n.
A naturally occurring protein that is a specific inhibitor of endothelial proliferation and a potent angiogenesis inhibitor. It is under investigation as a potential cancer therapy.

angiostatin

(an″jē-ō-stat′ĭn) [ angio- + statin]
A protein fragment of plasminogen that inhibits the growth of blood vessels, possibly by blocking the enzyme ATP synthase on the endothelium. It may shrink malignant tumors by decreasing their blood supply.

angiostatin

A degradation product of PLASMINOGEN that interferes with the development of blood vessels (angiogenesis) and offers promise as an anticancer agent. Growth of tumours beyond about 3 cu. mm. depends on the development of a good blood supply by the growth of small blood vessels. This applies both to the primary tumour and to any remote deposits (mestastases) of spread cancer. Trials have shown that angiostatin can cause early tumours to die from lack of a blood supply. See also ENDOSTATIN.
References in periodicals archive ?
Shing et al., "Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma," Cell, vol.
Ito et al., "Angiostatin induces endothelial cell apoptosis and activation of focal adhesion kinase independently of the integrin-binding motif RGD," Proceedings of the National Academy of Sciences of the United States of America, vol.
VEGF and PDGF mRNA expression was increased in the OX-LDL-injected group when compared with the PBS group (P <0.01, n = 10; Figures 4(a) and 4(b)), meanwhile angiostatin mRNA expression was increased in the Sal A-pretreated group (P < 0.05, n = 10; Figure 4(d)).
Angiostatin inhibits coronary angiogenesis during impaired production of nitric oxide.
Oppositely, macrophage elastase produced by tumor-associated macrophages cleaves plasminogen, thrombospondin, and type XVIII collagen generating anti-angiogenic molecules, such as angiostatin, thrombospondin fragments, and endostatin, respectively.
Likewise, PLG is activated by proteolysis and converted to plasmin and angiostatin which inhibit angiogenesis through diminishing activation of mitogen-activated protein kinases (Redlitz et al., 1999).
Macrophages are known to specifically secrete MMP-12, which leads to enhanced generation of angiostatin [29] and thereby suppresses tumour growth by halting angiogenesis.
Mainly, the tumor suppressor role of these MMPs is related to their ability to degrade plasminogen, collagen XVIII, and collagen IV to produce natural angiogenic inhibitors, such as angiostatin, endostatin, and tumstatin [4].
Ma, "Therapeutic potential of angiostatin in diabetic nephropathy," Journal of the American Society of Nephrology, vol.
Ashley et al., "Endothelial cell surface [F.sub.1]-[F.sub.0] ATP synthase is active in ATP synthesis and is inhibited by angiostatin," Proceedings of the National Academy of Sciences of the United States of America, vol.
In May 1998, the New York Times published a front-page story by Gina Kolata extolling two new chemical compounds "that can eradicate any type of cancer, with no obvious side effects and no drug resistance--in mice." Kolata reported on the findings of Judah Folkman, of Boston Children's Hospital, whose 30 years of work led to the discovery of angiostatin and endostatin.
It also appears that the MMP system may be involved in regulating angiogenesis in a much more complex manner (Joseph et al., 2008).In addition, MMPs may be responsible for the generation of natural angiostatic substances such as angiostatin, which inhibits vascular endothelial cell proliferation and is the proteolytic product of plasminogen (16).