ANGPTL4

(redirected from angiopoietin-like 4)

ANGPTL4

A gene on chromosome 19p13.3 that encodes angiopoietin-like protein 4, which is expressed in endothelial cells in response to hypoxia. It is directly involved in regulating glucose homeostasis, lipid metabolism and insulin sensitivity; it may act as a regulator of angiogenesis and modulate tumourigenesis, and may protect endothelial cells by secreted factors. It reduces endothelial cell motility and inhibits sprouting and tube formation.
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Tyynismaa et al., "Serum angiopoietin-like 4 protein levels and expression in adipose tissue are inversely correlated with obesity in monozygotic twins," Journal of Lipid Research, vol.
In this article, we report that Chi preferentially induced two important PPAR target genes, ANGPTL4 (angiopoietin-like 4) and PDK4 (pyruvate dehydrogenase kinase, isozyme 4), which are involved in lipid metabolism and insulin sensitization, relative to Ros and Pio.
Tan, "Angiopoietin-like 4: a decade of research," Bioscience Reports, vol.
Amolo, "Short chain fatty acids stimulate Angiopoietin-like 4 synthesis in human colon adenocarcinoma cells by activating, A-?" Molecular Cellular Biology, vol.
Angiopoietin-like 4 (Angptl4) protein is a physiological mediator of intracellular lipolysis in murine adipocytes.
Sumant Singh Chugh in the UAB Division of Nephrology said his research team, studying transgenic rats, discovered that in some forms of nephrotic syndrome, a protein called Angiopoietin-like 4 is over-produced in specialized cells called podocytes.
By feeding sialic acid precursor ManNAc to transgenic rats that over-produce Angiopoietin-like 4 in podocytes, the researchers were able to increase the amount of protein-bound sialic acid, and reduce the amount of protein leakage into the urine by more than 40 percent.
Angiopoietin-Like 4 (ANGPTL4): Structure and Expression Patterns
The angiopoietin-like 4 (ANGPTL4) protein was discovered for the first time in 2000 by three independent research groups.
Gololobov et al., "Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL)," Journal of Biological Chemistry, vol.
Tan, "Emerging roles of angiopoietin-like 4 in human cancer," Molecular Cancer Research, vol.
Chomel et al., "Extracellular matrix-bound angiopoietin-like 4 inhibits endothelial cell adhesion, migration, and sprouting and alters actin cytoskeleton," Circulation Research, vol.