ANGPTL3

(redirected from angiopoietin-like 3)

ANGPTL3

A gene on chromosome 1p31.1-p22.3 that encodes angiopoietin-like protein 3, which is expressed primarily in the liver.

Molecular pathology
ANGPTL3 mutations are associated with familial hypobetalipoproteinaemia type 2.
References in periodicals archive ?
announced positive pivotal Phase 3 results for evinacumab, an investigational angiopoietin-like 3 (ANGPTL3) antibody, in patients with homozygous familial hypercholesterolemia (HoFH).
(NASDAQ: REGN) today announced positive pivotal Phase 3 results for evinacumab, an investigational angiopoietin-like 3 (ANGPTL3) antibody, in patients with homozygous familial hypercholesterolemia (HoFH).
Evinacumab, which has a Breakthrough Therapy designation from the FDA, is the company's investigational angiopoietin-like 3 antibody.
Regeneron announced positive pivotal Phase 3 results for evinacumab, an investigational angiopoietin-like 3 antibody, in patients with homozygous familial hypercholesterolemia.
The following factors prepared at 800 ng/mL were assayed and exhibited no cross-reactivity or interference: recombinant human angiopoietin-1, angiopoietin-2, angiopoietin-4, and angiopoietin-like 3 and recombinant mouse angiopoietin-3 and angiopoietin-like 3.
Gololobov et al., "Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL)," Journal of Biological Chemistry, vol.
Abbreviations: ANGPTL3, angiopoietin-like 3; ANGPTL4, angiopoietin-like 4; Cox-2, cyclooxygenase-2; ERK, extracellular signal-regulated kinases; FFA, free fatty acids; HIF-1[alpha], hypoxia-inducible factor-1 alpha; IGF-1, insulin-like growth factor-1; IL-1[beta], interleukin-1 beta; IL-6, interleukin-6; IL-8, interleukin-8; LDL, low-density lipoprotein; LPL, lipoprotein lipase; MAPK, mitogen-activated protein kinase; PAI-1, plasminogen activator inhibitor-1; PGE2, prostaglandin E2; PKB[alpha], protein kinase B alpha; PPARs, peroxisome proliferator-activated receptors; ROS, reactive oxygen species; Src, V-SRC Avian Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene; TG, triglycerides; TNF-[alpha], tumor necrosis factor-alpha].
ISIS-ANGPTL3Rx, which is an antisense drug targeting angiopoietin-like 3 protein (ANGPTL3) and an independent risk factor for cardiovascular disease, is designed to act as a broad dyslipidemia agent, according to the company.
Familial hypocholesterolemia has received recent attention with the identification of mutations in the ANGPTL3 [2] (angiopoietin-like 3) and PCSK9 (proprotein convertase subtilisin/kexin type 9) genes as novel causes of low cholesterol concentrations (2).
In this study, subjects with elevated triglycerides achieved substantial and statistically significant mean reductions in angiopoietin-like 3 (ANGPTL3), triglycerides and LDL-cholesterol of up to 83 percent, 66 percent, and 35 percent, respectively.