ANGPT2

(redirected from angiopoietin 2)

ANGPT2

A gene on chromosome 8q23.1 that encodes angiopoietin 2, a secreted glycoprotein which, like other angiopoietins, binds to endothelial cell-specific tyrosine-protein kinase receptor. Angiopoietin 2 is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2/TEK); it disrupts ANGPT1’s vascular remodelling activity and may induce endothelial cell apoptosis.
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Most studies have reported vascular endothelial growth factor (VEGF), angiopoietin 1 (Ang-1), and angiopoietin 2 (Ang-2) to be potent regulators of microvascular remodelling in health and atherosclerotic diseases [8].
Caption: Figure 4: Changes in (a) SDF-1, (b) angiopoietin 2, and (c) angiopoietin 1 levels in ALL patients after successful chemotherapy before and after G-CSF treatment; Wilcoxon test was used.
Balonov et al., "Circulating angiopoietin 2 correlates with mortality in a surgical population with acute lung injury/adult respiratory distress syndrome," Shock, vol.
In further study the more specific attention should be focused on the correlation between cystatin C and even angiopoietin 2, which appeared to be a relevant predictor of renal dysfunction in acute pancreatitis patients [38].
The current study addresses this issue, focusing on angiopoietin 2 (Ang-2) and endothelial cell-specific molecule-1 (endocan) in ARDS patients.
Hellpap et al., "Angiopoietin 2 and cardiovascular disease in dialysis and kidney transplantation," American Journal of Kidney Diseases, vol.
Walsh et al., "Notch signalling pathways mediate synovial angiogenesis in response to vascular endothelial growth factor and angiopoietin 2," Annals of the Rheumatic Diseases, vol.
In hypoxic conditions, expression of hypoxia inducible factoralpha increases rapidly which in turn activates genes that encode for proangiogenic growth factors, such as vascular endothelial growth factor, basic fibroblast growth factor, angiopoietin 1 and angiopoietin 2, placental growth factor, and platelet-derived growth factor-B [29].
Kanda, "Angiopoietin 2 stimulates migration and tube-like structure formation of murine brain capillary endothelial cells through c-Fes and c-Fyn," Journal of Cell Science, vol.
(20) Angiopoietin 2 (Ang2) and vascular EGF (VEGF) inductions correlate remarkably well with this process.
Yao et al., "Hydrogen sulfide ameliorates acute lung injury induced by infrarenal aortic cross-clamping by inhibiting inflammation and angiopoietin 2 release," Journal of Vascular Surgery, no.
Harijith et al., "Increased hyperoxia-induced lung injury in nitric oxide synthase 2 null mice is mediated via angiopoietin 2," American Journal of Respiratory Cell and Molecular Biology, vol.