ANGPT2

(redirected from angiopoietin 2)

ANGPT2

A gene on chromosome 8q23.1 that encodes angiopoietin 2, a secreted glycoprotein which, like other angiopoietins, binds to endothelial cell-specific tyrosine-protein kinase receptor. Angiopoietin 2 is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2/TEK); it disrupts ANGPT1’s vascular remodelling activity and may induce endothelial cell apoptosis.
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Patients were shown to have elevated markers, including angiopoietin 2, chemokine IL-8, hepatocyte growth factor, soluble thrombomodulin, and serum nitrates.
A Complete Histologic Approach to Gastrointestinal Biopsy From Hematopoietic Stem Cell Transplant Patients With Evidence of Transplant-Associated Gastrointestinal Thrombotic Microangiopathy
Vitreous levels of angiopoietin 2 and vascular endothelial growth factor in patients with proliferative diabetic retinopathy," American Journal of Ophthalmology, vol.
Therapy Effects of Bone Marrow Stromal Cells on Ischemic Stroke
compensatory proangiogenic (10) factors by host cells, for instance VEGF, PlGF, G-CSF, osteopontin, angiopoietin 2, PDGFA, and SDF1[alpha] BMDC mobilization of myeloid Shojaei et al.
Targeting the tumor microenvironment for cancer therapy
Similar to the angiopoietin 2 (Ang-2) expression, the angiogenesis antagonist, promotes apoptosis to increase the production of the pro-apoptotic BAX proteins and to increase oxidation of fatty acids in endothelial cells via activation of the Kinase A protein (13,20).
Efectos del tratamiento con peptidos similares a leptina sobre factores asociados con el control de grasa corporal en ratas Wistar alimentadas con dieta alta en grasa
20) Angiopoietin 2 (Ang2) and vascular EGF (VEGF) inductions correlate remarkably well with this process.
Expression of EphB4 in head and neck squamous cell carcinoma
Phase 1b safety trial of CVX-060, an intravenous humanized monoclonal CovX body inhibiting angiopoietin 2 (ang-2), with sunitinib (Poster discussion, Abstract #3032, June 2)
Pfizer To Present New Data In Advanced Kidney, Lung And Hematologic Cancers At 2012 ASCO Annual Meeting
First-in-human dose-escalation safety and PD trial of a novel humanized monoclonal CovX body inhibitor of angiopoietin 2 and vascular endothelial growth factor.
Pfizer To Present New Research From Fifteen Compounds Highlighting Multiple Approaches To Targeting Cancer At 2011 ASCO Annual Meeting
the regulatory factors; vascular endothelial growth factor (VEGF), platelet derived growth factor (PDGF), angiopoietin 1, angiopoietin 2, etc.
Optimata Granted Patent for Modeling Angiogenesis and Providing Optimal Treatment
Findings Published in Nature Medicine Show Potential for RNAi Therapeutic Targeting Angiopoietin 2
Alnylam and Yale University Scientists Demonstrate Therapeutic Silencing of Disease Target Associated with Acute Lung Injury Using RNAi

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