ANGPT2

(redirected from angiopoietin 2)

ANGPT2

A gene on chromosome 8q23.1 that encodes angiopoietin 2, a secreted glycoprotein which, like other angiopoietins, binds to endothelial cell-specific tyrosine-protein kinase receptor. Angiopoietin 2 is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2/TEK); it disrupts ANGPT1’s vascular remodelling activity and may induce endothelial cell apoptosis.
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Most studies have reported vascular endothelial growth factor (VEGF), angiopoietin 1 (Ang-1), and angiopoietin 2 (Ang-2) to be potent regulators of microvascular remodelling in health and atherosclerotic diseases [8].
Circulating Angiogenic Growth Factors in Diabetes Patients with Peripheral Arterial Disease and Exertional Leg Pain in Ghana
Caption: Figure 4: Changes in (a) SDF-1, (b) angiopoietin 2, and (c) angiopoietin 1 levels in ALL patients after successful chemotherapy before and after G-CSF treatment; Wilcoxon test was used.
Very Small Embryonic-Like Stem Cells, Endothelial Progenitor Cells, and Different Monocyte Subsets Are Effectively Mobilized in Acute Lymphoblastic Leukemia Patients after G-CSF Treatment
Balonov et al., "Circulating angiopoietin 2 correlates with mortality in a surgical population with acute lung injury/adult respiratory distress syndrome," Shock, vol.
Predictive Value of Combined LIPS and ANG-2 Level in Critically 111 Patients with ARDS Risk Factors
In further study the more specific attention should be focused on the correlation between cystatin C and even angiopoietin 2, which appeared to be a relevant predictor of renal dysfunction in acute pancreatitis patients [38].
Urinary Extracellular Vesicles: Potential Biomarkers of Renal Function in Diabetic Patients
The current study addresses this issue, focusing on angiopoietin 2 (Ang-2) and endothelial cell-specific molecule-1 (endocan) in ARDS patients.
Angiopoietin-2 Levels as Predictors of Outcome in Mechanically Ventilated Patients with Acute Respiratory Distress Syndrome
Hellpap et al., "Angiopoietin 2 and cardiovascular disease in dialysis and kidney transplantation," American Journal of Kidney Diseases, vol.
High Circulating Levels of ANGPTL2: Beyond a Clinical Marker of Systemic Inflammation
Walsh et al., "Notch signalling pathways mediate synovial angiogenesis in response to vascular endothelial growth factor and angiopoietin 2," Annals of the Rheumatic Diseases, vol.
Angiogenesis Dysregulation in Psoriatic Arthritis: Molecular Mechanisms
In hypoxic conditions, expression of hypoxia inducible factoralpha increases rapidly which in turn activates genes that encode for proangiogenic growth factors, such as vascular endothelial growth factor, basic fibroblast growth factor, angiopoietin 1 and angiopoietin 2, placental growth factor, and platelet-derived growth factor-B [29].
Comparative analysis of cardiovascular development related genes in stem cells isolated from deciduous pulp and adipose tissue
Kanda, "Angiopoietin 2 stimulates migration and tube-like structure formation of murine brain capillary endothelial cells through c-Fes and c-Fyn," Journal of Cell Science, vol.
Signaling network map of endothelial TEK tyrosine kinase
(20) Angiopoietin 2 (Ang2) and vascular EGF (VEGF) inductions correlate remarkably well with this process.
Expression of EphB4 in head and neck squamous cell carcinoma
Yao et al., "Hydrogen sulfide ameliorates acute lung injury induced by infrarenal aortic cross-clamping by inhibiting inflammation and angiopoietin 2 release," Journal of Vascular Surgery, no.
Hydrogen Sulfide Prevents Formation of Reactive Oxygen Species through PI3K/Akt Signaling and Limits Ventilator-Induced Lung Injury
Harijith et al., "Increased hyperoxia-induced lung injury in nitric oxide synthase 2 null mice is mediated via angiopoietin 2," American Journal of Respiratory Cell and Molecular Biology, vol.
Hyperoxia exacerbates postnatal inflammation-induced lung injury in neonatal BRP-39 null mutant mice promoting the M1 macrophage phenotype

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