ARO-ANG3 is a subcutaneously administered RNA interference -based investigational medicine targeting angiopoietin
like protein 3 (ANGPTL3) being developed for the treatment of dyslipidemias, such as HoFH, and metabolic diseases.
It is a greater component of the family of angiogenic factors, which contains the placental growth factor, angiopoietin
, basic fibroblast growth factor and the VEGF family (A, B, C, D, and E) [7, 8].
Adipogenic differentiation and lipogenesis are known to depend on autocrine stimulation, e.g., with angiopoietin
II, insulin-like growth factor, nitric oxide, VEGF or adiponectin (reviewed in Huber et al., 2015b; Volz et al., 2016), which might have been diluted by the higher medium volume.
Among these factors it can be pointed to the vascular endothelial growth factor, the fibroblast growth factor (FGF), the hepatocyte growth factor, and angiopoietin
. [6,8,9] Angiopoietins
are human growth factors that are also especially effective on the process of angiogenesis.
Vallance et al., "Obligatory participation of macrophages in an angiopoietin
2-mediated cell death switch," Development, vol.
Most studies have reported vascular endothelial growth factor (VEGF), angiopoietin
1 (Ang-1), and angiopoietin
2 (Ang-2) to be potent regulators of microvascular remodelling in health and atherosclerotic diseases .
Furthermore, all endothelial cells were shown to express angiopoietin
receptor (Tie-2) that may be activated by both angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2).
Balonov et al., "Circulating angiopoietin
2 correlates with mortality in a surgical population with acute lung injury/adult respiratory distress syndrome," Shock, vol.
This proliferation may be stimulated by several prolymphangiogenic factors of VEGF and angiopoietin
Hellpap et al., "Angiopoietin
2 and cardiovascular disease in dialysis and kidney transplantation," American Journal of Kidney Diseases, vol.