angiomyofibroblastoma

angiomyofibroblastoma

(an'gē-ō-mī'ō-fī'brō-blas-tō'mă),
Benign well-circumscribed tumor composed of blood vessels, myofibroblastic cells, and fat cells, usually found in the pelviperineal region of women.

angiomyofibroblastoma

A benign, well-circumscribed, < 3 cm tumour, often of vulvar soft tissue, which affects young to middle-aged women.

DiffDx
Aggressive angiomyxoma, cellular angiofibroma.
Mentioned in ?
References in periodicals archive ?
It is an infiltrative tumour, whereas angiomyofibroblastoma is well circumscribed (this characteristic can also be identified on Magnetic Resonance Imaging [MRI]].
Cellular angiofibroma: A benign neoplasm distinct from angiomyofibroblastoma and spindle cell lipoma.
The microscopic differential diagnosis includes endometrial stromal nodule, angiomyofibroblastoma, and perivascular epithelioid cell tumor.
Clinically and morphologically, cellular angiofibroma can simulate other benign tumours like leiomyoma, angiomyofibroblastoma, spindle cell lipoma and perineurioma (1, 5).
Normal vulvar tissue and different lesions of vulva have been surveyed for hormonal milieu receptors such as vulvar cancers, Cavernous lymphangiomas, angiomyofibroblastoma, angiomyxoma, indicating ER and PR importance in disease pathogenesis (16, 17, 18, 19) the positivity rate for ER in normal vulvar tissue varies from 33-100% (20) and it's also positive in most of CA lesions and normal vaginal epithelium (5).
Hamartoma, lymphadenoma, angiomyofibroblastoma, cellular angiofibroma, sarcomas, angiomyxoma and dermatofibrosarcoma protuberans are other differential diagnosis.
There was strong nuclear positivity in 90% of AAMs compared with weaker reactivity in 27% of fibroepithelial stromal polyps and no staining in angiomyofibroblastoma or cellular angiofibroma.
3) Angiomyofibroblastoma is a rare benign mesenchymal tumor occurring in middle aged women.
1] CAF share pathological features of angiomyofibroblastoma and aggressive angiomyxoma (AAM), but do not fall into either category.
Included in this latter group are nodular fasciitis, fibromatoses, angiomyofibroblastoma, sarcomas with a prominent myofibroblastic component, and malignant fibrous histiocytoma.
The differential diagnosis of aggressive angiomyxoma includes fibroepithelial stromal polyp, angiomyofibroblastoma, myxomas, superficial angiomyxoma, myxoid neurofibroma, myxoid liposarcoma, and myxofibrosarcoma.
1] More recently, since the first description by Fletcher et al,[2] angiomyofibroblastoma (AMFB) of the female vulvovaginal tract has been recognized as an essentially benign angiomyxoid neoplasm histologically distinct from AAM.