It is an infiltrative tumour, whereas angiomyofibroblastoma
is well circumscribed (this characteristic can also be identified on Magnetic Resonance Imaging [MRI]].
Cellular angiofibroma: A benign neoplasm distinct from angiomyofibroblastoma
and spindle cell lipoma.
The microscopic differential diagnosis includes endometrial stromal nodule, angiomyofibroblastoma
, and perivascular epithelioid cell tumor.
Clinically and morphologically, cellular angiofibroma can simulate other benign tumours like leiomyoma, angiomyofibroblastoma
, spindle cell lipoma and perineurioma (1, 5).
Normal vulvar tissue and different lesions of vulva have been surveyed for hormonal milieu receptors such as vulvar cancers, Cavernous lymphangiomas, angiomyofibroblastoma
, angiomyxoma, indicating ER and PR importance in disease pathogenesis (16, 17, 18, 19) the positivity rate for ER in normal vulvar tissue varies from 33-100% (20) and it's also positive in most of CA lesions and normal vaginal epithelium (5).
Hamartoma, lymphadenoma, angiomyofibroblastoma
, cellular angiofibroma, sarcomas, angiomyxoma and dermatofibrosarcoma protuberans are other differential diagnosis.
There was strong nuclear positivity in 90% of AAMs compared with weaker reactivity in 27% of fibroepithelial stromal polyps and no staining in angiomyofibroblastoma
or cellular angiofibroma.
is a rare benign mesenchymal tumor occurring in middle aged women.
1] CAF share pathological features of angiomyofibroblastoma
and aggressive angiomyxoma (AAM), but do not fall into either category.
Included in this latter group are nodular fasciitis, fibromatoses, angiomyofibroblastoma
, sarcomas with a prominent myofibroblastic component, and malignant fibrous histiocytoma.
The differential diagnosis of aggressive angiomyxoma includes fibroepithelial stromal polyp, angiomyofibroblastoma
, myxomas, superficial angiomyxoma, myxoid neurofibroma, myxoid liposarcoma, and myxofibrosarcoma.
1] More recently, since the first description by Fletcher et al, angiomyofibroblastoma
(AMFB) of the female vulvovaginal tract has been recognized as an essentially benign angiomyxoid neoplasm histologically distinct from AAM.