angiomotin


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angiomotin

A protein encoded by AMOT on Xq23 that mediates angiostatin inhibition of migration and tube formation of endothelial cells, and plays a central role in tight junction maintenance via the complex formed with ARHGAP17, regulating the uptake of polarity proteins at tight junctions. It may play a role in the assembly of endothelial cell–cell junctions.
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Long non-coding RNA small nucleolar RNA host gene 12 (SNHG12) promotes cell proliferation and migration by upregulating angiomotin gene expression in human osteosarcoma cells.