angiolymphoid hyperplasia with eosinophilia

(redirected from angiolymphoid hyperplasia)

an·gi·o·lym·phoid hy·per·pla·si·a with e·o·sin·o·phil·i·a

solitary or multiple small benign cutaneous erythematous nodules, occurring mainly on the head and neck in young adults, characterized by dermal proliferation of blood vessels with vacuolated histiocytoid endothelial cells and with a varied infiltrate of eosinophils, lymphocytes which may form follicles, and histiocytes.
Synonym(s): Kimura disease

angiolymphoid hyperplasia with eosinophilia

An uncommon idiopathic condition with some features of Kimura disease, which presents in adults as one or more red-blue papules, plaques, or nodules in the head and neck, less commonly in the hands, shoulders, and elsewhere. It is unknown whether it is neoplastic or reactive.
Prognosis ALHE is clinically benign but persistent and treatment is refractory.


Tetsuji, 20th century Japanese pathologist.
Kimura disease - solitary or multiple small benign cutaneous erythematous nodules. Synonym(s): angiolymphoid hyperplasia with eosinophilia
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References in periodicals archive ?
Background and Objective: Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare, benign, vasoproliferative entity of unknown etiology.
Angiolymphoid hyperplasia with eosinophilia (AHE) has an unknown pathogenesis but is considered a reactive phenomenon, possibly in response to or in association with an underlying vascular malformation.
Angiolymphoid hyperplasia with eosinophilia (ALHE), sometimes called epithelioid hemangioma, is a benign vascular tumor.
Differential diagnosis on imaging would include tuberculosis, lymphoma, metastatic adenopathy, primary parotid tumors, angiolymphoid hyperplasia with eosinophilia (ALHE), and cat-scratch disease [Table 2].
KD can be confused clinically and histologically with angiolymphoid hyperplasia with eosinophilia (ALHE), also known as epitheloid hemangioma, which is a rare but distinctive vascular tumor typically occurring in women.
Angiolymphoid hyperplasia with eosinophilia (ALHE), also named epithelioid hemangioma (EH), is an inflamed vascular tumefaction of uncertain pathogenesis, characterized by proliferation of histiocytoid endothelial cells with prominent lymphocytic and eosinophilic infiltration.
1,2] First described in 1969 as superficial angiolymphoid hyperplasia with eosinophilia, the lesion is microscopically typified by well-formed capillary-sized vessels, epithelial-like endothelial cells with large nucleoli and prominent nucleoli, absent nuclear atypia, and often secondary inflammatory infiltrate.
Kimura's disease: a clinico-pathological study of 21 cases and its distinction from angiolymphoid hyperplasia with eosinophilia.
Histologically it should be differentiated with Angiolymphoid hyperplasia, Kaposi sarcoma, Dermatofibrosarcoma protruberans Surgical excision of lesions is first line therapy.
Angiolymphoid hyperplasia with eosinophilia, first described by Wells and Whimster in 1969, is a rare benign vascular tumor.
The differential diagnosis of Kimura disease includes such entities as eosinophilic granuloma, Mikulicz disease, acute nonlymphocytic leukemia, Hodgkin disease, follicular lymphoma, angioimmunoblastic lymphadenopathy, and angiolymphoid hyperplasia with eosinophilia.
Unilateral angiolymphoid hyperplasia with eosinophilia involving the left arm and hand.