angiolymphoid hyperplasia with eosinophilia

(redirected from angiolymphoid hyperplasia)

an·gi·o·lym·phoid hy·per·pla·si·a with e·o·sin·o·phil·i·a

solitary or multiple small benign cutaneous erythematous nodules, occurring mainly on the head and neck in young adults, characterized by dermal proliferation of blood vessels with vacuolated histiocytoid endothelial cells and with a varied infiltrate of eosinophils, lymphocytes which may form follicles, and histiocytes.
Synonym(s): Kimura disease

angiolymphoid hyperplasia with eosinophilia

An uncommon idiopathic condition with some features of Kimura disease, which presents in adults as one or more red-blue papules, plaques, or nodules in the head and neck, less commonly in the hands, shoulders, and elsewhere. It is unknown whether it is neoplastic or reactive.
Prognosis ALHE is clinically benign but persistent and treatment is refractory.


Tetsuji, 20th century Japanese pathologist.
Kimura disease - solitary or multiple small benign cutaneous erythematous nodules. Synonym(s): angiolymphoid hyperplasia with eosinophilia
Mentioned in ?
References in periodicals archive ?
Angiolymphoid hyperplasia with eosinophilia (ALHE), sometimes called epithelioid hemangioma, is a benign vascular tumor.
A prior excisional biopsy of one of the nodules in March 2012 was reported as angiolymphoid hyperplasia with eosinophilia (ALHE).
Kimura's disease and angiolymphoid hyperplasia with eosinophilia: two disease entities in the same patient: case report and review of the literature.
1,2] First described in 1969 as superficial angiolymphoid hyperplasia with eosinophilia, the lesion is microscopically typified by well-formed capillary-sized vessels, epithelial-like endothelial cells with large nucleoli and prominent nucleoli, absent nuclear atypia, and often secondary inflammatory infiltrate.
Subcutaneous angiolymphoid hyperplasia with eosinophilia.
Kimura's disease: a clinico-pathological study of 21 cases and its distinction from angiolymphoid hyperplasia with eosinophilia.
The differential diagnosis includes angiolymphoid hyperplasia with eosinophilia (ALHE), Hodgkin lymphoma, angioimmunoblastic T-cell lymphoma, Langerhans cell histiocytosis, florid follicular hyperplasia, Castleman disease, dermatopathic lymphadenopathy, allergic granulomatosis of Churg and Strauss, drug reaction, and parasitic lymphadenitis.
The differential diagnosis of Kimura disease includes such entities as eosinophilic granuloma, Mikulicz disease, acute nonlymphocytic leukemia, Hodgkin disease, follicular lymphoma, angioimmunoblastic lymphadenopathy, and angiolymphoid hyperplasia with eosinophilia.
Unilateral angiolymphoid hyperplasia with eosinophilia involving the left arm and hand.
This finding suggested either Kimura's disease or angiolymphoid hyperplasia with eosinophilia (ALHE).
Kimura disease is sometimes confused with angiolymphoid hyperplasia with eosinophilia, Hodgkin lymphoma, angioimmunoblastic T-cell lymphoma, florid follicular hyperplasia, Castleman disease, and lymphadenopathy secondary to drug reactions and parasitic infections.
Kimura's disease can also be confused with angiolymphoid hyperplasia with eosinophilia (ALHE).