Five of the most common causes are exudative macular degeneration, high/ pathological myopia, choroidal rupture, angioid streaks, and punctate inner choroidopathy.
Angioid streaks are full thickness breaks in calcified and thickened Bruch's membrane.
Angioid streaks in the retina arise from fractures in the calcified elastic lamina of Bruch's membrane and are associated with subretinal neovascularization; bleeding from the newly formed vessels may impair vision (3).
These patients were found to bear angioid streaks and skin lesions similar to those observed in PXE.
Opthalmologic examination showed bilateral colloid bodies and peripapillary atrophy with angioid
These other diseases include pathologic myopia (PM), ocular histoplasmosis syndrome (OHS), angioid streaks, CNV due to certain retinal abnormalities, and idiopathic causes, among others.
Based on these findings, the application seeks approval of Visudyne therapy for diseases other than AMD characterized by CNV, even though the etiology of the formation of CNV is different for each disease, such as multifocal choroiditis, angioid streaks, certain retinal abnormalities, idiopathic or unknown causes, and many other rare conditions.
There are several other conditions that occur in relatively young patients, such as Ocular Histoplasmosis and Angioid
Streaks, in which breaks in Bruch's membrane occur and are complicated by subfoveal choroidal neovascularization.
The most common cause by far is age-related macular degeneration (AMD), but other causes include myopia, choroidal inflammatory conditions such as punctate inner choroidopathy or the presumed ocular histoplasmosis syndrome, trauma, and angioid
streaks is a hereditary condition resulting in a degeneration of Bruch's membrane and the RPE.
Rare associations include retinitis pigmentosa (RP) and angioid
Based on these findings, the supplemental NDA seeks approval of Visudyne therapy for PM, OHS and a variety of other diseases characterized by CNV, in particular those in which the lesions are typically predominantly classic, even though the etiology of the formation of CNV is different for each disease, such as multifocal choroiditis, angioid
streaks, certain retinal abnormalities, idiopathic or unknown causes, and many other rare conditions.