Multiple organs are affected, including the skin, eyes, and cardiovascular system, and the pathogenic changes include lax and inelastic skin, angioid
streaks in the retina, and mineralization of the internal elastic lamina of midsized arteries, including the cerebral, coronary, gastrointestinal and peripheral vasculature.
8) Ophthalmic and systemic diseases commonly associated with drusen are retinitis pigmentosa, angioid
streaks, Usher syndrome, Noonan syndrome and Alagille syndrome.
Acute stroke after intravitreal bevacizumab to treat choroidal neovascularization due to angioid
streaks in pseudoxanthoma elasticum: A severe systemic adverse event after an off-label procedure.
It is characterized by specific skin lesions, angioid
streaks and other degenerative changes of the retina and widespread vascular calcification leading to gastrointestinal bleeding, premature myocardial infarction, cerebrovascular disease, peripheral vascular disease and hypertension.
The differential diagnosis of peripapillary choroidal neovascularization in young patients includes optic nerve drussen, peripapillary pseudopodal pigment epithelial and choroidal atrophy, angioid
streaks, pattern dystrophy, choroidal osteoma and uveitis.
Disk drusen and angioid
streaks in pseudoxanthoma elasticum.
Examination of the fundus did not reveal retinal de-tachment, angioid
streaks or other abnormalities.
There were angioid
streaks on funduscopic examination (FIGURE 2).
streaks, which occur in the retina, have been found more commonly in patients with Paget disease.
streaks in the retina arise from fractures in the calcified elastic lamina of Bruch's membrane and are associated with subretinal neovascularization; bleeding from the newly formed vessels may impair vision (3).
Opthalmologic examination showed bilateral colloid bodies and peripapillary atrophy with angioid
There are several other conditions that occur in relatively young patients, such as Ocular Histoplasmosis and Angioid
Streaks, in which breaks in Bruch's membrane occur and are complicated by subfoveal choroidal neovascularization.