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A pilot study of angiogenin in heart failure with preserved ejection fraction: a novel potential biomarker for diagnosis and prognosis?
Serum VEGF, bFGF and angiogenin levels were significantly elevated in patients with HCC (413.
It was concluded that high serum levels of VEGF, bFGF, angiogenin and endostatin were observed in patients with HCC.
70 Sensitivity, ng/L 10 1 k Angiogenin
MIP-1 [beta] n 16/17 12/17 Average amount (SE) 9.
A surprising aspect of angiogenin is that its amino acid sequence has similarities to that of another human protein, an enzyme that breaks up RNA.
While Vallee kept his work on angiogenin under wraps, other scientists have described other blood-vessel stimulating chemicals.
The ancillary activity confuses the issue," he says, adding that angiogenin is 1,000 times as potent in triggering blood vessel growth as is the fibroblast growth factor.
For example, in addition to its angiogenic effects, angiogenin specifically degrades transfer RNA, but not messenger RNA (14).
Angiogenin is a cytotoxic, tRNA-specific ribonuclease in the RNase A superfamily.