Acute resistance exercise increases skeletal muscle angiogenic growth factor
VEGF-A, a pro-survival factor for endothelial cells (ECs), is believed to be a well known angiogenic growth factor
in angiogenesis, and it can act both by inducing EC proliferation and by stimulating EC migration (Ferrara et al.
Potential applications of our DNA delivery technology include DNA vaccines for infectious diseases or cancer, in which the expressed protein is an immunogen; cancer immunotherapeutics, in which the expressed protein is an immune system stimulant; and cardiovascular therapies, in which the expressed protein is an angiogenic growth factor
It blocks all VEGF-A isoforms plus placental growth factor (PIGF), another angiogenic growth factor
that appears to play a role in tumor angiogenesis.
Stegmann's distinguished medical career includes nine years of Cardiovascular Surgery at Hannover Medical School, Germany, and twenty years as a Cardiovascular Surgeon, Professor of Surgery, and Director of the Department of Thoracic & Cardiovascular Surgery, Fulda Medical Center, in Fulda, Germany, where he initiated the first human clinical trials using angiogenic growth factor
therapy to grow new arteries in patients suffering from coronary artery disease.
There have been efforts to treat ischemia by creating new blood vessels and delivering angiogenic growth factors
like vascular endothelial growth factor (VEGF) to ischemic sites.