angiogenic growth factor


Also found in: Dictionary, Thesaurus, Legal, Financial, Encyclopedia.

angiogenic growth factor

Any of a group of polypeptides that stimulate the formation of new blood vessels. They include agents like vascular endothelial growth factor (VEGF) and blood vessel fibroblastic growth factor (bFGF). These factors are active in healing wounds, chronic inflammatory conditions, retrolental fibroplasia, and malignant tumors, which require new blood vessels for continued growth.
See also: factor
References in periodicals archive ?
Acute resistance exercise increases skeletal muscle angiogenic growth factor expression.
VEGF-A, a pro-survival factor for endothelial cells (ECs), is believed to be a well known angiogenic growth factor in angiogenesis, and it can act both by inducing EC proliferation and by stimulating EC migration (Ferrara et al.
Potential applications of our DNA delivery technology include DNA vaccines for infectious diseases or cancer, in which the expressed protein is an immunogen; cancer immunotherapeutics, in which the expressed protein is an immune system stimulant; and cardiovascular therapies, in which the expressed protein is an angiogenic growth factor.
It blocks all VEGF-A isoforms plus placental growth factor (PIGF), another angiogenic growth factor that appears to play a role in tumor angiogenesis.
Stegmann's distinguished medical career includes nine years of Cardiovascular Surgery at Hannover Medical School, Germany, and twenty years as a Cardiovascular Surgeon, Professor of Surgery, and Director of the Department of Thoracic & Cardiovascular Surgery, Fulda Medical Center, in Fulda, Germany, where he initiated the first human clinical trials using angiogenic growth factor therapy to grow new arteries in patients suffering from coronary artery disease.
There have been efforts to treat ischemia by creating new blood vessels and delivering angiogenic growth factors like vascular endothelial growth factor (VEGF) to ischemic sites.