angiogenic growth factor


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angiogenic growth factor

Any of a group of polypeptides that stimulate the formation of new blood vessels. They include agents like vascular endothelial growth factor (VEGF) and blood vessel fibroblastic growth factor (bFGF). These factors are active in healing wounds, chronic inflammatory conditions, retrolental fibroplasia, and malignant tumors, which require new blood vessels for continued growth.
See also: factor
References in periodicals archive ?
Decidual vascularization and the expression of angiogenic growth factors and proteases in first trimester spontaneous abortions.
Acute resistance exercise increases skeletal muscle angiogenic growth factor expression.
However, it has been shown that angiogenic growth factors are already present in preinvasive lesions [17].
If gene transfer occurs, angiogenic growth factor protein may be produced, stimulating angiogenesis (growth of new blood vessels).
"The application of an angiogenic growth factor like FGF-1 is not able to replace bypass surgery.
The study followed 31 Weill Cornell patients who were diagnosed with severe coronary artery disease and were given a direct injection into their heart muscle of gene therapy called adenovirus encoding angiogenic growth factor, or AdVEGF121.
VEGF-A, a pro-survival factor for endothelial cells (ECs), is believed to be a well known angiogenic growth factor in angiogenesis, and it can act both by inducing EC proliferation and by stimulating EC migration (Ferrara et al.
Potential applications of Vical's DNA delivery technology include DNA immunotherapeutics for cancer, in which the expressed protein is an immune system stimulant; DNA vaccines for infectious diseases, in which the expressed protein is an immunogen; and cardiovascular therapies, in which the expressed protein is an angiogenic growth factor. Vical is developing certain infectious disease vaccines and cancer therapeutics internally.
Potential applications of our DNA delivery technology include DNA vaccines for infectious diseases or cancer, in which the expressed protein is an immunogen; cancer immunotherapeutics, in which the expressed protein is an immune system stimulant; and cardiovascular therapies, in which the expressed protein is an angiogenic growth factor. We have retained all rights to our internally developed product candidates.