angiogenic gene therapy


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Agent

AGENT
Angiogenic GENe Therapy. A clinical trial evaluating the safety & efficacy of an angiogenic gene therapy, Ad5-FGF4 (fibroblast growth factor 4).
Primary endpoint 1-month, 3-month exercise tolerance.
Conclusion Early data indicate that Ad5-FGF4 significantly improves exercise time in treated patients.

Agent
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angiogenic gene therapy

Cardiology An investigational therapy that delivers a growth factor gene to diseased coronary arteries evoking growth factor production and stimulating angiogenesis and formation of blood vessels that bypass occluded coronary arteries
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References in periodicals archive ?
Cardium's therapeutic approach to the treatment of myocardial ischemia associated with coronary heart disease has been the focus of the most widely-conducted clinical studies for Angiogenic Gene Therapy (AGENT-1 through AGENT-4), which involved 663 patients at more than 100 U.
s Generx [Ad5FGF-4] cardiovascular angiogenic gene therapy as a one-time treatment for improving exercise tolerance in patients who have angina that is refractory to standard medical therapy and not amenable to conventional revascularisation procedures (coronary artery bypass surgery and percutaneous coronary intervention and stents), the company said.
The addition of this new gene broadens our portfolio of therapeutic genes and expands the range of commercial opportunities for Collateral in the field of cardiovascular angiogenic gene therapy," said Christopher J.