angiogenic factor

angiogenic factor

Any of a group of substances present in the circulation (most of which are polypeptides—e.g., angiogenin, fibroblast growth factor, transforming growth factors and some lipids) which play a role in blood vessel formation. Angiogenic factors are increased after myocardial ischaemia.

angiogenic factor

Any of a group of substances present in the circulation–most of which are polypeptides–eg, angiogenin, fibroblast growth factor, transforming growth factors, some lipids which help form blood vessels; AFs ↑ after myocardial ischemia
References in periodicals archive ?
Angiogenic factor levels are biomarkers, predictors of outcomes that, when available in routine clinical laboratories, provide guidance for management of patients allowing physicians to make realistic predictions of outcome early enough to consider interventions.
As for all screening tests the positive predictive value of angiogenic factor screening depends on the population tested.
RESULTS: A 48-month follow-up revealed that the combination treatment with VK and ACE-I markedly inhibited the cumulative recurrence of HCC in association with suppression of the serum level of the vascular endothelial growth factor (VEGF); a central angiogenic factor.
Among these marker proteins, placental growth factor (PLGF), a member of the vascular endothelial cell growth factor (VEGF) family, is produced chiefly by the placenta and is a potent angiogenic factor.
At that time he thought there was something called tumor angiogenic factor that was being released, and he hypothesized that if we could stop this process we could ultimately stabilize the disease.
Shh can increase angiogenic factor ANGPT1, and its upregulation possibly enhanced ANGPT1-mediating reciprocal interactions with TIE-2/Akt pathway between the endothelium and surrounding matrix and mesenchyme, and subsequent blood vessel maturation and stability (Fiedler et al.
It also acts as an angiogenic factor inducing blood vessels, promotes tumoral invasion, activates cancer stem cells, and in some tumors, induces metastases.
A number of cell types, including keratinocytes, macrophages, fibroblasts, and endothelial cells, are known to produce VEGE allowing for a massive secretion of this important angiogenic factor, particularly in the setting of hypoxia, which is often observed in wounds.
It increases production of vascular endothelial growth factor (VEGF), the main angiogenic factor, which in turn enhances the expression of CXCR4 receptor in endothelial cells, in an autocrine loop (3).
Combined, these data provide strong evidence that NO plays a role in the regulation of angiogenic factor expression by luteal microvascular pericytes.