We evaluated the concentrations of a select panel of cytokines, including innate immune mediators (interferon [IFN]-[gamma], interleukin [IL]-15, IFN-P); inflammatory factors (IL-6, IL-18, soluble intercellular adhesion molecule 1 [sICAM-1]); chemokines (CC-motif chemokine ligand [CCL] 3, CCL-4, CXC-motif chemokine ligand [CXCL] 1, CXCL-8, CXCL-10); hematopoietic factors (granulocyte colony-stimulating factor [G-CSF], granulocyte-macrophage colony-stimulating factor); the angiogenic factor
vascular endothelial growth factor A (VEGF-A); and proteases (matrix metalloproteinase [MMP]-2, MMP-9).
Cost and resource implications with serum angiogenic factor
estimation in the triage of pre-eclampsia.
VEGF is a soluble angiogenic factor
produced by epithelial and stromal cells in upper layers of the uterine endometrium.
(1) speculated that the excessive invasion of the myometrium could facilitate the local accrual of VEGF and a significant decrease in the maternal circulatory levels of this angiogenic factor
. Although we did not study the local levels of VEGF at the decidual placental interface, we confirmed that circulating maternal VEGF levels in the preoperative blood samples were significantly lower in women with PP than in the control group.
reported that ELISA-based quantitative measurements of urinary angiogenic factor
levels in voided urine samples were reliable , and all the studies included herein that assessed urinary ANG levels in bladder carcinoma reported that ANG levels were significantly elevated in patients with cancer compared with those in healthy controls.
The RNA expression level of the angiogenic factor
VEGF peaked on day 7 and was higher in the ECM/SVF-gel treated group than in the SVF treated group at all time points, whereas expression of the angiogenic factor
bFGF peaked on day 4 in the ECM/SVF-gel treated group and was higher than that in the SVF treated group between days 2 and 10 (Figure 7).
Taken together, these findings suggest that gonadotropins induce the production of an angiogenic factor
that stimulates the proliferation of capillaries from the vascular wreath present in the theca layer and promotes follicular development.
Identification of an angiogenic factor
that when mutated causes susceptibility to Klippel-Trenaunay syndrome.
Vascular Endothelial Growth Factor A (VEGF-A) is the most specific and prominent angiogenic factor
among all VEGF family members.
Inhibition of the angiogenic factor
plays a crucial role in tumor inhibition, and LCE made from liquid molecules extracted from shark cartilage in frozen form has strong antiangiogenic properties by targeting VEGF and MMPs and reduces solid tumor size; chemotherapy combined with VEGF inhibition has shown a much better result in killing cancer cells.
VEGF, as a direct angiogenic factor
, has a main role in angiogenesis [8-11].
Tryptase is a novel, potent angiogenic factor
," Journal of Clinical Investigation, vol.