It was further demonstrated that different modifications of the CAM assay are versatile tools for the in vivo evaluation of small quantities (1-2 mg) of natural compounds or newly synthesized compounds, enabling the detection of possible angiogenic
or antiangiogenic effects of the test compound to evaluate its property as an anticancer or angiogenic
drug candidature ([17, 18]).
model is an in vivo model for anti-angiogenic
drug screening and target discovery, and increasing evidence suggested that anti-angiogenic
compounds effective in mammals would elicit similar effects in Zebrafish (Taraboletti 2004).
isoforms are down- regulated in many angiogenic
diseases such as various cancers, arthritis and cardiovascular diseases (33-35).
These findings support the theory that preeclampsia and its complications may be due to an imbalance in circulating angiogenic
Banked frozen serum samples were assayed to determine levels of vitamin D (total 25-hydroxyvitamin D) and the angiogenic
markers sFlt-1, PlGF, and vascular endothelial growth factor (VEGF).
MMP-2 is involved in a number of angiogenic
steps, namely, migration, invasion, and tube formation.
factors are measurable in the serum of cancer patients, providing possible markers for breast cancer.
We believe that our approach to treating angina by infusing angiogenic
adenovectors to trigger the growth of new blood vessels in the heart represents a best-in-class technique -- and while we appreciate and respect other companies' interests in attempting to secure competing patent claims, we intend to continue to defend and to strengthen our IP portfolio for delivering angiogenic
DNA sequences to the heart.
genes transported by a modified version of a common cold virus into the heart muscle
Envisioned as a procedure that could be administered by interventional cardiologists, Ad5FGF-4 involves a one-time administration of an adenoviral gene therapy vector containing the human Fibroblast Growth Factor 4 (FGF4) angiogenic
gene delivered into the coronary arteries through a standard catheter.
Tumors and metastases may arise as small avascular masses that subsequently induce the angiogenic
ingrowths that are required to allow for further growth of early tumors.
patent application covering a unique, new angiogenic
agent, which is designed to produce new blood vessels in the hearts of persons suffering from blockages in their coronary arteries, a process called angiogenesis.