angiogenesis inhibitor


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Related to angiogenesis inhibitor: tumor angiogenesis

inhibitor

 [in-hib´ĭ-tor]
1. any substance that interferes with a chemical reaction, growth, or other biologic activity.
2. a chemical substance that inhibits or checks the action of a tissue organizer or the growth of microorganisms.
3. an effector that reduces the catalytic activity of an enzyme.
ACE i's (angiotensin-converting enzyme i's) see angiotensin-converting enzyme inhibitors.
angiogenesis inhibitor a group of drugs that prevent growth of new blood vessels into a solid tumor.
aromatase i's a class of drugs that inhibit aromatase activity and thus block production of estrogens; used to treat breast cancer and endometriosis.
C1 inhibitor (C1 INH) a member of the serpin group, an inhibitor of C1, the initial component activated in the classical complement pathway. Deficiency of or defect in the protein causes hereditary angioedema.
carbonic anhydrase inhibitor an agent that inhibits the enzyme carbonic anhydrase; used in treatment of glaucoma and sometimes for epilepsy, familial periodic paralysis, acute mountain sickness, and kidney stones of uric acid.
cholinesterase inhibitor anticholinesterase.
COX-2 i's (cyclooxygenase-2 i's) a group of nonsteroidal antiinflammatory drugs that act by inhibiting cyclooxygenase-2 activity; they have fewer gastrointestinal side effects than other NSAIDs. Two members of the group are celecoxib and rofecoxib.
gastric acid pump inhibitor an agent that inhibits gastric acid secretion by blocking the action of H+,K+-ATPase at the secretory surface of gastric parietal cells; called also proton pump i.
HIV protease inhibitor any of a group of antiretroviral drugs active against the human immunodeficiency virus; they prevent protease-mediated cleavage of viral polyproteins, causing production of immature viral particles that are noninfective. Examples include indinavir sulfate, nelfinavir mesylate, ritonavir, and saquinavir.
HMG-CoA reductase i's a group of drugs that competitively inhibit the enzyme that catalyzes the rate-limiting step in cholesterol biosynthesis, and are used to lower plasma lipoprotein levels in the treatment of hyperlipoproteinemia. Called also statins.
membrane inhibitor of reactive lysis (MIRL) protectin.
monoamine oxidase inhibitor any of a group of drugs that inhibit the action of monoamine oxidase, the enzyme that breaks down norepinephrine and serotonin, prescribed for their antidepressant action; the most widely used ones are isocarboxazid, phenelzine, and tranylcypromine. They are also used in the prevention of migraine.
α2-plasmin inhibitor α2-antiplasmin.
plasminogen activator inhibitor (PAI) any of several regulators of the fibrinolytic system that act by binding to and inhibiting free plasminogen activator. Their concentration in plasma is normally low, but is altered in some disturbances of bodily hemostasis. PAI-1 is an important fast-reacting inhibitor of t-plasminogen activator and u-plasminogen activator. Its synthesis, activity, and release are highly regulated; elevated levels of it have been described in a number of disease states. PAI-2 is a normally minor inhibitor that greatly increases in concentration during pregnancy and in certain disorders. PAI-3 is protein C inhibitor.
platelet inhibitor any of a group of agents that inhibit the clotting activity of platelets; the most common ones are aspirin and dipyridamole. See also antiplatelet therapy.
protease inhibitor
1. a substance that blocks activity of endopeptidase (protease), such as in a virus.
protein C inhibitor the primary inhibitor of activated anticoagulant protein C; it is a glycoprotein of the serpin family of proteinase inhibitors and also inhibits several other proteins involved in coagulation (thrombin, kallikrein, and coagulation factors X and XI) and urokinase. Called also plasminogen activator inhibitor 3.
proton pump inhibitor gastric acid pump i.
reverse transcriptase inhibitor a substance that blocks activity of the reverse transcriptase of a retrovirus and is used as an antiretroviral agent. Some are nucleosides or nucleoside analogues, and those that are not are therefore often called non-nucleoside reverse transcriptase inhibitors.
selective serotonin reuptake inhibitor (SSRI) any of a group of drugs that inhibit the inactivation of serotonin by blocking its absorption in the central nervous system; used as antidepressants and in the treatment of obsessive-compulsive disorder and panic disorder.
serine protease inhibitor (serine proteinase inhibitor) serpin.
topoisomerase i's a class of antineoplastic agents that interfere with the arrangement of DNA in cells.

angiogenesis inhibitor

n.
A drug that blocks angiogenesis in cancerous tissue, thus interfering with tumor growth or metastasis.

angiogenesis inhibitor

A chemotherapy adjuvant (e.g., TNP-470, Avastin) that inhibits the angiogenesis required for tumour growth and survival, especially for metastastatic tumours.

angiogenesis inhibitor

Oncology A chemotherapy adjuvant which inhibits the angiogenesis required for tumor growth and survive, especially for metastastatic tumors See CAI, CM101, IFN-alpha, IL-12, Marimastat, Pentosan polysulfate, Platelet factor 4, Thalidomide, TNP-470.

angiogenesis inhibitor

One of a range of substances that block the development of new blood vessels (angiogenesis) and show promise as anticancer drugs. Cancers cannot grow beyond microscopic size unless they develop new blood vessels. If this is prevented they will regress or remain dormant and harmless. Research has shown that the angiogenesis inhibitors endostatin and angiostatin are capable of eliminating cancers of the breast, colon, prostate and brain in mice and can do so without undesirable side effects in the short term. These two drugs act in different ways and research on humans with cancer was started in mid-1998. The drugs are believed not to induce drug resistance in mice.
References in periodicals archive ?
Hanahan, "Effects of angiogenesis inhibitors on multistage carcinogenesis in mice," Science, vol.
Therefore, many natural or synthetic angiogenesis inhibitors, also called antiangiogenic agents, have been studied to prevent or slow the growth of cancer.
Angiogenesis inhibitors block the signaling of cancer-cell inducers to surrounding blood vessels and inhibit the vasoproliferation necessary for the growth, persistence, and metastasis of solid tumors (55).
Sato, "Multiple processing forms and their biological activities of a novel angiogenesis inhibitor vasohibin," Biochemical and Biophysical Research Communications, vol.
Despite the discovery of many such agents, the need for further research exists, because the angiogenesis inhibitors obtained so far are either very costly to synthesize, or they exhibit a number of side effects.
The clinical toxicity profile of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) targeting angiogenesis inhibitors; a review.
PTK/ZK is a novel, oral angiogenesis inhibitor that blocks all known VEGF receptor tyrosine kinases, which lead to tumor angiogenesis, growth and metastases.
TRIGR Therapeutics, a privately-owned company based in Irvine, California focused on the development and commercialisation of novel therapeutics, has expanded its bispecific immuno-oncology range with the global license of a clinical stage, dual angiogenesis inhibitor from ABL Bio, it was reported on Tuesday.
Bevacizumab introduces an angiogenesis inhibitor to traditional combinations of cytotoxic drugs, while cetuximab is an important antiepidermal growth factor receptor antibody.
Another NCI-sponsored study evaluating Neovastat (AE-941), an angiogenesis inhibitor derived from ultrafiltration of liquid dogfish shark cartilage, is ongoing.
CollaGenex Pharmaceuticals (NASDAQ: CGPI), Newton, Pa., has announced that the AIDS Malignancy Consortium (AMC), sponsored by the National Cancer Institute (NCI), has opened enrollment for a multi-center study to determine the efficacy of COL-3 (Metastat), an orally active angiogenesis inhibitor developed by CollaGenex Pharmaceuticals, in HIV-related Kaposi's sarcoma (KS).