angiogenesis


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Related to angiogenesis: Anti-angiogenesis, Angiogenesis inhibitors

angiogenesis

 [an″je-o-jen´ĕ-sis]
1. development of blood vessels in the embryo.
2. any formation of new blood vessels; see also neovascularization (def. 2) and revascularization. Called also angiopoiesis and vasculogenesis. adj., adj angiogenic.
tumor angiogenesis the induction of the growth of blood vessels from surrounding tissue into a tumor by a diffusible protein factor released by the tumor cells.

an·gi·o·gen·e·sis

(an'jē-ō-jen'ĕ-sis),
Development of new blood vessels.
Synonym(s): arteriogenesis
[angio- + G. genesis, production]

angiogenesis

(ăn′jē-ō-jĕn′ĭ-sĭs)
n. pl. angiogene·ses (-sēz′)
The formation of new blood vessels.

an′gi·o·gen′ic (-jĕn′ĭk) adj.

angiogenesis

The development of new blood vessels from pre-existing vessels. Angiogenesis plays a fundamental role in embryonic development, tissue and wound repair, resolution of inflammation, and onset of neoplasia. It is linked to an array of pathological conditions (e.g., cancer, diabetic retinopathy, rheumatoid arthritis).

angiogenesis

The sprouting of new blood vessels and capillary beds from existing vessels, which plays a fundamental role in embryonic development, tissue and wound repair, resolution of inflammation, and onset of neoplasia; angiogenesis is linked to certain pathologies–eg, cancer, diabetic retinopathy, rheumatoid arthritis

an·gi·o·gen·e·sis

(an'jē-ō-jen'ĕ-sis)
1. Development of blood vessels in the embryo. 2. Any formation of new blood vessels.
[angio- + G. genesis, production]

angiogenesis

The origination and development of new capillary blood vessels in normal or malignant tissue. Angiogenesis is necessary so that a growing or enlarging tissue, with its increasing metabolic needs, obtains an adequate blood supply providing oxygen, nutrients and waste drainage. Various angiogenetic factors are secreted by blood-deprived (ischaemic) cells and these operate on the inner lining (endothelium) of existing blood vessels to cause the budding out of new capillaries. Angiogenesis can be exploited in two ways in medicine-it can, in theory be inhibited in the treatment of CANCER, DIABETIC RETINOPATHY, obesity, ENDOMETRIOSIS and ATHEROSCLEROSIS; or it can be encouraged to treat heart attacks, ununited fractures, neurodegenerative disease, peripheral blood circulation deficiencies and baldness.

angiogenesis

process of forming new blood vessels, normally accompanies the growth of MALIGNANT tissue. TUMOURS need angiogenesis to provide the nutrients and oxygen for development and METASTATIS.

Angiogenesis

The formation of new blood vessels, for example, as a result of a tumor.

VEGF (vascular endothelial growth factor) 

A major protein involved in regulating the differentiation and proliferation of vascular endothelial cells thus promoting the growth of new blood vessels (angiogenesis). VEGF is essential for normal embryonic development and contributes to the maintenance and repair of tissues. There are several VEGF proteins, depending on the number of amino acids that they contain (e.g. VEGF 121, VEGF 165, VEGF 189 and VEGF 206). However, under certain circumstances (e.g. higher than normal levels of VEGF as happens in hypoxia) it may participate in cancerous processes, inflammatory processes (e.g. rheumatoid arthritis) and ocular neovascularization as in exudative (wet) age-related macular degeneration and diabetic retinopathy. Anti-VEGF drugs are used to inhibit the action of VEGF. See anti-VEGF drugs.
References in periodicals archive ?
When this balance is disturbed, the result is either too much or too little angiogenesis. The abnormal growth of blood vessels, either excessive or insufficient, is now recognized as a "common denominator" underlying many deadly and debilitating conditions, including cancer, skin diseases, age-related blindness, diabetic ulcers, cardiovascular disease, stroke, and many others ([1]).
Generally considered, CD34, a marker of vascular endothelial progenitor cell, is propitious to endothelial repair and regeneration and tumor angiogenesis.25 CD34+ cells are dominantly located in vascular endothelium and its immunohistochemistry is normally utilized as a tool for the quantification of MVD.
As mentioned above, the function of VEGF in angiogenesis is accompanied by PDGFs.
Overexpression of Bach1b Impairs the Developmental Angiogenesis of Zebrafish.
Si bien es cierto que es conocida la accion inhibitoria de AAS sobre las enzimas cicloxigenasas 1 y 2 (COX-1 y COX2), impidiendo asi la sintesis de prostaglandinas a partir del acido araquidonico, el mecanismo por el cual inhibe la angiogenesis no esta totalmente estudiado.
As in many solid tumors, the development of angiogenesis is also an important step in the pathogenesis of bladder cancer (7).
"While we anticipated that improving angiogenesis in adipose tissue would make the adipose healthier, we were surprised that altering the levels of a particular protein, FoxO, in endothelial cells exerted such a broad influence on whole-body glucose levels and weight gain.
Sema3B acts as a tumor suppressor in lung cancer and inhibits the formation of endothelial cells tubes in an in vitro angiogenesis; however, this function was abrogated upon mutation at the furin cleavage site (13).
Although the synergistic effects of CX, Li, and VPA in tumor cell proliferation and metastasis have been investigated in previous studies, to the best of our knowledge, the possible synergistic effects of CX, Li, and VPA on angiogenesis have yet to be fully elucidated.
Under natural circumstances, the inhibitor factors of angiogenesis outnumber the stimulating factors, and therefore, the process of angiogenesis is impeded.
However, the association between Notch signaling-mediated angiogenesis and poststroke brain remodeling via the improved CBF has not been investigated.