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Related to angioedema: Hereditary angioedema


a localized edematous reaction of the deep dermis or subcutaneous or submucosal tissues appearing as giant wheals; urticaria is the same physiologic reaction occurring in the superficial portions of the dermis.
hereditary angioedema an autosomal dominant disorder of the complement system manifested as recurrent episodes of edema of the skin, upper respiratory tract, and gastrointestinal tract. It may be mediated by such factors as minor trauma, sudden changes in environmental temperature, and sudden emotional stress. adj., adj angioede´matous.


Recurrent large circumscribed areas of subcutaneous or mucosal edema of sudden onset, usually disappearing within 24 hours; frequently, an allergic reaction to foods or drugs.


Rapid swelling of the subcutaneous tissues and submucosal membranes, often accompanied by urticaria.

angioneurotic oedema

(1) Acquired angioedema, a chronic and potentially fatal condition characterised by abdominal pain and episodic localised subcutaneous, periorbital, periocular and laryngeal oedema, due to an absence of C1 esterase inhibitor.
Clinical findings
Recurrent oedema; abdominal pain; laryngeal oedema, which may compromise breathing.

History of recurrent angioedema, abnormally low or absent C1 esterase inhibitor in blood.
Allergies (e.g., foods, pollen, insect bites); drugs (e.g., ACE inhibitors, salicylates); stress; exposure to cold, water, sunlight or heat.

Epinephrine, antihistamines, corticosteroids (androgens).

(2) Hereditary angioneurotic oedema, see there


1. A general term for a vascular reaction of the deep dermis, subcutaneous or submucosal tissues, which corresponds to localized edema 2º to vasodilation and ↑ capillary permeability.
2. Angioneurotic edema, see there.


1. Recurrent large circumscribed areas of subcutaneous edema of sudden onset, usually disappearing within 24 hours; seen mainly in young women, frequently as an allergic reaction to foods or drugs.


An allergic skin disease characterized by patches of confined swelling involving the skin the layers beneath the skin, the mucous membranes, and sometimes the viscera—called also angioneurotic edema, giant urticaria, Quincke's disease, or Quincke's edema.


Henry M., U.S. physician, 1844-1920.
Bannister disease - recurrent large circumscribed areas of subcutaneous edema, frequently an allergic reaction to foods or drugs. Synonym(s): angioedema


Heinrich Irenaeus, German physician, 1842-1922.
Quincke capillary pulsation - Synonym(s): Quincke pulse
Quincke disease - Synonym(s): Quincke edema
Quincke edema - recurrent, large, circumscribed areas of subcutaneous edema of sudden onset, usually disappearing within 24 hours. Synonym(s): angioedema; Milton disease; Milton urticaria; Quincke disease; Quincke I syndrome
Quincke meningitis - intracranial hypertension of unknown origin.
Quincke needle
Quincke pulse - capillary pulsation, a sign of arteriolar dilation and especially well seen in severe aortic insufficiency. Synonym(s): Quincke capillary pulsation; Quincke sign
Quincke puncture - a puncture into the subarachnoid space of the lumbar region to obtain spinal fluid for diagnostic or therapeutic purposes. Synonym(s): lumbar puncture
Quincke sign - Synonym(s): Quincke pulse
Quincke spinal needle
Quincke I syndrome - Synonym(s): Quincke edema


Recurrent large circumscribed areas of subcutaneous or mucosal edema of sudden onset, usually disappearing within 24 hours; often due to an allergic reaction to foods or drugs.
Synonym(s): angioneurotic edema.

Patient discussion about angioedema

Q. Is severe diarrhea sign of angioedema? I have sudden onset of painful diarrhea with stomach pain.

A. Severe diarrhea can be a sign of angioedema but it is a very unlikely way of angioedema to show, especially if that is the only symptoms and there is no obvious seen swelling of skin or shortness of breath. Stomach ache with diarrhea is usually caused by an infection, most likely a viral infection, and should pass within a few days. If symptoms are unbarable or continue, you should see your doctor.

Q. What can cause an angioedema on 15 year old girl? I’ve been getting angioedema signs on my left arm for the past few weeks, not severe but it itches and sure don’t help my low-as-it-is self esteem…

A. The following may cause angioedema -

Animal dander
Certain medications (drug allergy)
Emotional stress
Exposure to water, sunlight, cold or heat
Foods (such as berries, shellfish, nuts, eggs, milk, other)
Insect bites

Hives or angioedema may also occur after an illness or infection.
Try to see if you were exposed to any of this and report it to your Dr.

More discussions about angioedema
References in periodicals archive ?
Global Hereditary angioedema Market, by Distribution Channel
- The report estimates that in 2017, there were approximately 402,700 prevalent cases of hereditary angioedema worldwide, and forecasts that number to increase to 440,600 prevalent cases by 2026.
Angioedema regressed quickly after medication and complete recovery of the lesions was observed within 2 days.
It should be noted that these data were recorded by patients and/or family members themselves and probably included other types of angioedema without urticaria (1).
"Once-daily oral administration of BCX7353 at a dose of 125 mg or more resulted in a significantly lower rate of attacks of hereditary angioedema than placebo," the authors write.
The patient was diagnosed with ACE inhibitor-induced angioedema and received treatment with 2 bags of fresh frozen plasma, leading to full remission of the facial and cervical edema.
Increased levels of C4a and C5a increase mast cell and basophil degranulation of vasoactive substances that contribute to angioedema [7].
"In multivariate logistic regression analysis, angioedema located in the head and neck region was nonsignificantly associated with admission (odds ratio (OR) 6.93 (p = 0.14, 95% CI 0.53-98.49)), while angioedema in peripheral sites was significantly associated with not being admitted (OR 0.15 (p = 0.05 95% CI, 0.01-0.95) (Table 6))."
Based on the clinical scenario, the patient's tentative diagnosis was ticagrelor-induced hypersensitivity reaction with angioedema as this was the only new medication he was given (he was on daily maintenance aspirin for his CAD and previously tolerated a 1-year course of clopidogrel after drug-eluting stent implantation).
Common side effects of IV tPA include intracerebral hemorrhage, systemic hemorrhage, and rarely angioedema. The incidence of angioedema increases in patients who also take an ACE inhibitor.
Hereditary angioedema (HAE) is an autosomal dominant-inherited disease estimated to affect around 1 in 50,000 individuals [1].