angiocentric glioma

angiocentric glioma

An indolent supratentorial glioma with perivascular distribution of neoplastic cells. 

Clinical findings
Patients usually present with drug-resistant focal epilepsy, usually of childhood onset.

Imaging
• FLAIR imaging—Solid, circumscribed, hyperintense, non-enhancing.
• MRI—T1-weighted images show cortical rim-like hyperintensities. Stalk-like extensions toward the ventricles in T2-weighted images and FLAIR are typical.
References in periodicals archive ?
Potential diagnoses included an infiltrating astrocytoma, an angiocentric glioma, and a diffuse variant of a low-grade astrocytoma such as a pilocytic astrocytoma.
MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism.
(37) Additionally, alterations in MYB and MYBL1, primarily fusion events, have been observed in angiocentric gliomas and low-grade astrocytomas.
Newly Codified Glial Neoplasms of the 2007 WHO Classification of Tumours of the Central Nervous System: Angiocentric Glioma, Pilomyxoid Astrocytoma and Pi tuicytoma.
They coined the term "monomorphous angiocentric glioma" for this tumor.
The pathology files were searched during a 20-year period of time (1989-2009) for tumors diagnosed as angiocentric glioma or tumors with pathologic descriptions potentially representing angiocentric glioma.
Angiocentric glioma is a low-grade (WHO grade I) cerebrocortical tumor of childhood with a characteristic angiocentric growth pattern.
Histopathologically, angiocentric glioma exhibits a perivascular growth pattern of bipolar spindle cells with mild pleomorphism, an infiltrative border, and lack of high-grade features such as elevated mitotic activity, necrosis, vascular proliferation, and meningeal extension.
The histogenesis of angiocentric glioma is a subject of debate, with postulated ependymal or radial glial cell origin.
The differential diagnosis of angiocentric glioma should include ependymoma and pilomyxoid astrocytoma.
Angiocentric glioma. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, eds.
Angiocentric glioma: a case report and review of the literature.