TGFBR3 and MGEA5 rearrangements in pleomorphic hyalinizing angiectatic tumors and the spectrum of related neoplasms.
Pleomorphic hyalinizing angiectatic tumor-analysis of 41 cases supporting evolution from a distinctive precursor lesion.
Clinicopathologic features of pleomorphic hyalinizing angiectatic tumor of soft parts.
 on 45 pediatric cases of CCSK showed the classic arborizing fibrovascular stroma in all the CCSK cases with variable myxoid, spindle, palisading, epithelioid, sclerosing, cellular, cystic, and angiectatic
PTX, a nonselective phosphodiesterase inhibitor, inhibits the conversion of cAMP to AMP, increases cAMP levels, improves cell function and hemorheology, and possesses an angiectatic
nasal polyps that clinically simulate a malignant process arch pathol lab med 124 (3): 406-410.
Using fluorescence in situ hybridization probes to detect rearrangements of TGFBR3 and MGEA5 in 31 pure MIFSs, 8 hybrid tumors, 2 pleomorphic hyalinizing angiectatic
tumors (PHATs), and 2 HFLTs, they observed that TGFBR3 and MGEA5 rearrangements were largely limited to hybrid HFLT-MIFS (6 of 8 cases), PHAT, and HFLT, and only rarely detected in pure MIFS.
These entities include benign lesions such as sclerotic fibroma, (2) cellular angiofibroma, (3) giant cell angiofibroma, (4) solitary fibrous tumor, (5) medallion-like dendrocyte hamartoma (plaquelike [CD34.sup.+] dermal fibroma), (6) pleomorphic fibroma, (7) cellular digital fibroma, (8) superficial acral fibromyxoma, (9) pleomorphic hyalinizing angiectatic tumor of soft parts, (10) and malignant lesions such as dermatofibrosarcoma protuberans (DFSP).
Pleomorphic Hyalinizing Angiectatic Tumor.--Pleomorphic hyalinizing angiectatic tumor (PHAT) comes into the differential diagnosis owing to its similar superficial location and paradoxical striking nuclear pleomorphism with low mitotic count.
[CD34.sup.+] Spindle Cell Neoplasms and Their Differential Diagnoses Fibrohistiocytic and fibroblastic neoplasm Dermatofibrosarcoma protuberans and giant cell fibroblastoma Myxoinflammatory fibroblastic sarcoma Solitary fibrous tumor Giant cell angiofibroma Lipofibromatosis Fibroma Superficial angiomyxoma Superficial acral fibromyxoma Cellular digital fibroma Cellular angiofibroma Superficial [CD34.sup.+] fibroblastic tumor Neural neoplasms Neurofibroma Nerve sheath myxoma Perineurioma Lipogenic neoplasms Spindle cell lipoma/pleomorphic lipomas Neoplasms of unknown lineage Pleomorphic hyalinizing angiectatic tumor of soft parts Epithelioid sarcoma Table 2.
Three cases of pleomorphic hyalinizing angiectatic tumor (PHAT) and 3 other cases of non-MIFS were tested, all of which were negative for t(1; 10).
(20,21) Pleomorphic hyalinizing angiectatic tumor also occurs at similar sites and age as HFLT, with a common biologic behavior.