Regarding IPR, at concentrations comparable to those used in practice, it can increase micronucleus formation and can be regarded as a potential aneugen
in plants (Gadeva and Dimitrov, 2008).
Thus, low-dose arsenite may be considered an aneugen
. In fact, an increased frequency of MN has been demonstrated in exfoliated bladder cells, buccal cells, sputum cells, and lymphocytes from arsenic-exposed populations (Rossman 2003).
In interpreting these findings, one must consider that although there are several examples of MN induction in human binucleated lymphocytes by known clastogenic exposures in vivo, evidence that the in vivo effects of an aneugen
can be expressed in the first in vitro division of a binucleated cell is scanty (31,32).