anergy


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anergy

 [an´er-je]
1. lack of energy; extreme passivity.
2. diminished reactivity to specific antigen(s). adj., adj aner´gic.

an·er·gy

(an'er-jē),
1. In a person, absence of the ability to generate a sensitivity reaction to substances expected to be antigenic (immunogenic, allergenic).
2. Lack of energy.
[G. an- priv. + energeia, energy, from ergon, work]

anergy

/an·er·gy/ (an´er-je)
1. extreme lack of energy.
2. diminished reactivity to one or more specific antigens.aner´gic

anergy

[an′ərjē]
Etymology: Gk, a, ergon, not work
1 lack of activity, lack of energy leading to inactivity.
2 an immunodeficient condition characterized by a lack of or diminished reaction to an antigen or group of antigens. This state may be seen in advanced tuberculosis and other serious infections, acquired immunodeficiency syndrome, and some malignancies. anergic, adj.

anergy

Depression or absence of an immune response to an antigen to which a host was previously sensitive. Anergy is characterised by decreased or absent lymphokine secretion by viable T cells when the T cell receptor is engaged by an antigen; it can be tested by loss of delayed hypersensitivity (e.g., to PPD, Candida antigens or DCNB).

Anergy can be induced in mature and differentiated CD4+ T cells by exposure to complexes of antigen and appropriate (self) MHC in absence of certain uncharacterised co-stimulatory signals on the antigen-presenting cells. In patients who have received blood transfusions, anergy may be induced by presentation of antigen by “nonprofessional” antigen-presenting cells.

anergy

Immunology Depression or absence of an immune response to an antigen to which the host was previously sensitive; it is characterized by ↓/absent lymphokine secretion by viable T cells when the T cell receptor is engaged by an antigen; it can be tested by loss of delayed hypersensitivity–eg, to PPD, Candida antigens, or DCNB. See Clonal anergy, Deletion. Cf Allergy.

an·er·gy

(an'ĕr-jē)
1. Absence of ability to generate a sensitivity reaction in a subject to substances expected to be antigenic (immunogenic, allergenic) in that individual.
2. Lack of energy.
[G. an- priv. + energeia, energy, from ergon, work]

anergy

Specific immunological tolerance in which T cells and B cells fail to respond normally by producing an immune response to antigens. The state can be reversed.

anergy

loss or weakening of the immune response to an irritating agent or ANTIGEN. A T-CELL that encounters an antigen and does not respond to it is anergic. Contrasts with ALLERGY where there is an overreaction, rather than lack of reaction, to a substance.

an·er·gy

(an'ĕr-jē)
1. In a person, absence of the ability to generate a sensitivity reaction to substances expected to be antigenic (immunogenic, allergenic).
2. Lack of energy.
[G. an- priv. + energeia, energy, from ergon, work]

anergy (an´urjē),

n in terms of hypersensitivity, an inability to react to specific antigens (i.e., lack of reaction to intradermally injected antigens in measles, Hodgkin's sarcoma, and overwhelming tuberculosis).

anergy

diminished reactivity to specific antigen(s).
References in periodicals archive ?
Anergy can be defined as the hidden factors that either inhibit the creation or contribute to damage the corporate value of the company.
Low-exergy" refers to using anergy and reducing exergy -- qualities and quantity of energy -- instead of fossil fuels.
CTLA-4 upregulation during HIV infection: Association with anergy and possible target for therapeutic intervention.
Low doses of antigen mostly induce active suppression, whereas high doses favor deletion and anergy (21).
These mechanisms include relative T cell inactivity or T cell anergy [12, 13], T cell depletion by apoptosis [14, 15] and active immune suppression [16, 17].
T cell memory, anergy and immunotherapy in breast cancer.
The only significant predictor of vaccine response was IgG2 level at the time of immunization for tetanus, PPV23, and KLH vaccines, he said, noting that "age, methotrexate dose, concomitant corticosteroid use, diagnosis of diabetes mellitus, skin test anergy [less than 5 mm induration], IgM, IgA, total IgG, and IgGl, IgG3, and IgG4 subsets were not predictors of immunization response, nor did rituximab affect total IgG or IgG2 levels.
The interpretation of the test is complicated by cross-reactions in persons either vaccinated with BCG or exposed to environmental mycobacteria, and false-negative results can occur owing to anergy.
Assuming heat flow from the surroundings is pure anergy and [E.
B7 is the critical signal that tells T cells to become functional or enter an inactive state called anergy or tolerance.
Reversal of coccidioidal anergy in vivo by dendritic cells from patients with disseminated coccidioidomycosis.
AdapT technology uses proprietary two-peptide molecular constructs to selectively cause the death of only those immune T-cells that are involved in autoimmune disease, asthma, allergy, and transplant rejection, by having these disease causing T-cells undergo apoptosis (programmed cell death) and anergy (a state of immune unresponsiveness).