anergic


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Related to anergic: anergy

an·er·gic

(an-er'jik),
Relating to, or marked by, anergy.
Farlex Partner Medical Dictionary © Farlex 2012

anergic

adjective Inactive; lacking energy; pertaining to anergy.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

an·er·gic

(an-ĕr'jik)
Relating to, or marked by, anergy.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

anergy

(an′ĕr-jē)
Impairment in cell-mediated immune responsiveness to stimulation by an antigen.
anergic (ă-nĕr′jik, an′ĕr), adjective
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
The results of several studies have suggested that HIV-Infected persons diagnosed as anergic have a greater risk for active TB than do nonanergic, Ppd-negative, HIV-Infected persons from the same population (15-19).
In addition, two (22%) of the nine anergic patients had clinically active pulmonary TB; both had sputum specimens that were smear- and culture-positive.
Although patient PB-NK and PE-NK cells are not fully anergic as they respond to stimulation by IL-2 in the culture medium, however, addition of TGF[beta] or iPE or tmPE fluids resulted in a strong inhibition of this crucial effector function of NK cells, even in healthy donor NK cells, suggesting a predominant role for the PE tumor microenvironment in the establishment of an alternative NK cell activation status.
Enk, "[CD4.sup.+] and [CD8.sup.+] anergic T cells induced by interleukin-10treated human dendritic cells display antigen-specific suppressor activity," Blood, vol.
Kanchwala et al., "Low levels of NF-[kappa]B/p65 mark anergic [CD4.sup.+] T cells and correlate with disease severity in sarcoidosis," Clinical and Vaccine Immunology, vol.
Without these adjunct signals, T cells become anergic or undergo apoptosis and thus the response against that antigen is abrogated [32].
Macian, "Interleukin 2 gene transcription is regulated by Ikaros-induced changes in histoneacetylation in anergic T cells," Blood, vol.
Atthisstage encounterof Bcellswith autoantigens results in negative selection; however, defect in retention of self-antigens due to abnormal expression of CR1 and CR2 may lead to loss of deletion and escape of anergic, self-reactive B cells to the periphery.
Additionally, the same group demonstrated that anergic B cells are metabolically quiescent, while B cells chronically exposed to high BAFF level undergo a metabolic switch, rapidly increasing glycolysis on stimulation [48].
These anergic DCs have the capability to favour the differentiation of regulatory T cells and to prolong significantly allograft survival.
Parmiani, "Tumor immunity as autoimmunity: tumor antigens include normal self proteins which stimulate anergic peripheral T cells," Immunology Today, vol.
In addition, NKT cells become anergic for several weeks upon engagement of their TCRs [64].