There are two groups of families of neurosteroids: the inhibitory neurotransmitter receptor families of pregnane neurosteroids that include allopregnanolone and aIlotetrahydrodeoxycorticosterone, and the excitatory neurotransmitter receptor families of androstane neurosteroids, such as androstanediol and etiocholanone.
They include androstanediol (5[alpha]-androstane-3[alpha], 17[beta]-diol) and estradiol.
001 for trend after adjustment for age, date of visit, body mass index, systolic blood pressure, blood cholesterol, cigarette smoking, diabetes mellitus, alcohol intake, physical activity, social class, education, dehydroepiandrosterone sulfate, androstanediol
glucuronide, and sex hormone binding globulin).
Three of the metabolites comigrated with androstenedione, dihydrotestosterone, and androstanediol.
It is of interest that adult female fathead minnows (Pimephales promelas) eliminate androstanediol at a higher rate than males (9), matching the pattern we observed in total oxido-reduction metabolite formation in Lake Woodruff animals.
The testosterone metabolites androsterone and etiocholanolone can be measured in 24-hour urine, while the best androgen metabolites in the serum to assess are dihydrotestosterone and androstanediol
glucuronide, which concentration is on the average double that of testosterone.
The induction of prostatic hypertrophy in the dog with androstanediol
We believe that a higher incidence of low-differentiated tumors in the finasteride-treated arm observed in the PCPT is caused by altering the normal differentiation of prostatic epithelium in the environment lacking the natural ER[beta] ligand--3[beta] androstanediol
and 5-androstenediol profiling for detecting exogenously administered dihydrotestosterone, epitestosterone, and dehydroepiandrosterone: potential use in gas chromatography isotope ratio mass spectrometry.
But the next metabolite after DHT is the frequently ignored androstanediol
(testosterone [right arrow] DHT [right arrow] androstanediol
Confirming testosterone administration by isotope ratio mass spectrometric analysis of urinary androstanediols
Confirming testosterone administration by isotope ratio mass spectrometry analysis of urinary androstanediols