androgen-independent prostate cancer


Also found in: Acronyms.

androgen-independent prostate cancer

A form of prostate cancer characterised by metastases, aggressive clinical behaviour and a poor response to androgen ablation. Most androgen-independent prostate cancers express high levels of androgen receptor gene transcripts, which may be due to androgen receptor mutations.
References in periodicals archive ?
Deregulated anti-apoptotic proteins Bc1-2 and Bcl-xL have been shown to function as oncoproteins in the development of androgen-independent prostate cancer and chemoresistance in prostate cancer (Catz and Johnson 2003; Lebedeva et al.
The role of microRNA-221 and microRNA-222 in androgen-independent prostate cancer cell lines.
Because androgen-independent prostate cancers often become resistant to antiandrogens, we tested the effect of the antiandrogen flutamide on DHT-stimulated PSA mRNA levels in control and CAsE-PE cells.
Dysregulated expression of androgen-responsive and nonresponsive genes in the androgen-independent prostate cancer xenograft model CWR22-R1.
This study will focus on patients with androgen-independent prostate cancer, relapsing or progressing after a previous line of docetaxel-based chemotherapy.
at the Cleveland Clinic Foundation, Cleveland, OH, examined the dose-limiting toxicities, maximum tolerated dose, and the effects on PSA levels of VELCADE and docetaxel, both given weekly for two out of three weeks, in patients with advanced androgen-independent prostate cancer.
to initiate the CRITICAL (CRyotherapy and IntraTumoral Immunotherapy with immature dendritic Cells (AutoLogous)) trial, a clinical trial examining the potential of a novel combination of cryoablation and intra-tumoral injection of "virgin" dendritic cells (VDC2008) to treat men with metastatic androgen-independent prostate cancer.
This study demonstrates that modified citrus pectin enhances the cytotoxic effect of Doxorubicin in both androgen-dependent but more importantly in androgen-independent prostate cancer," said integrative medicine pioneer Isaac Eliaz, M.
Antiandrogen withdrawal alone or in combination with ketoconazole in androgen-independent prostate cancer patients: a phase III trial (CALGB 9583).
Snake-venom toxin shows promise in stopping the growth of androgen-independent prostate cancer cells, according to a recent report in Molecular Cancer Therapeutics.
Immunicon Corporation (NASDAQ-GM:IMMC) announced today that it filed with the FDA a request for clearance of the CellSearch[TM] Circulating Tumor Cell Kit as an aid in the monitoring of patients with metastatic androgen-independent prostate cancer.

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