androgen-independent prostate cancer


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androgen-independent prostate cancer

A form of prostate cancer characterised by metastases, aggressive clinical behaviour and a poor response to androgen ablation. Most androgen-independent prostate cancers express high levels of androgen receptor gene transcripts, which may be due to androgen receptor mutations.
References in periodicals archive ?
Deregulated anti-apoptotic proteins Bc1-2 and Bcl-xL have been shown to function as oncoproteins in the development of androgen-independent prostate cancer and chemoresistance in prostate cancer (Catz and Johnson 2003; Lebedeva et al.
The role of microRNA-221 and microRNA-222 in androgen-independent prostate cancer cell lines.
Because androgen-independent prostate cancers often become resistant to antiandrogens, we tested the effect of the antiandrogen flutamide on DHT-stimulated PSA mRNA levels in control and CAsE-PE cells.
29) Scientists are keenly interested in this study, because it showed that MCP could preside at the deaths of both androgen-dependent and androgen-independent prostate cancers.
Dysregulated expression of androgen-responsive and nonresponsive genes in the androgen-independent prostate cancer xenograft model CWR22-R1.
Today there is a tremendous unmet medical need for treating the disease, particularly for end-stage or androgen-independent prostate cancer for which therapeutic options are limited.
to initiate the CRITICAL (CRyotherapy and IntraTumoral Immunotherapy with immature dendritic Cells (AutoLogous)) trial, a clinical trial examining the potential of a novel combination of cryoablation and intra-tumoral injection of "virgin" dendritic cells (VDC2008) to treat men with metastatic androgen-independent prostate cancer.
Patrick Ling and colleagues demonstrated that gamma-tocotrienol downregulates the expression of prostate cancer stem cell markers in androgen-independent prostate cancer cell lines.
Antiandrogen withdrawal alone or in combination with ketoconazole in androgen-independent prostate cancer patients: a phase III trial (CALGB 9583).
Snake-venom toxin shows promise in stopping the growth of androgen-independent prostate cancer cells, according to a recent report in Molecular Cancer Therapeutics.
This multicenter, randomized open-label Phase 2 single-arm study is enrolling patients with metastatic androgen-independent prostate cancer who have developed disease progression during or within 60 days of receiving docetaxel-based chemotherapy or demonstrated intolerance to docetaxel-based therapy.
POMEGRANATE EXTRACT INHIBITS ANDROGEN-INDEPENDENT PROSTATE CANCER GROWTH THROUGH A NUCLEAR FACTOR-KAPPAB-DEPENDENT MECHANISM.

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