androgen ablation

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Related to androgen suppression: Androgen Deprivation Therapy, androgen ablation

androgen ablation

The therapeutic reduction of circulating androgens (testosterone and 5alpha-dihydrotestosterone) by either orchiectomy or by an luteinizing hormone-releasing hormone (LHRH) agonist. Androgen ablation is commonly used in metastatic prostate cancer and results in disease attenuation (12–18 months) in up to 80% of patients. Androgen ablation can be augmented by flutamide, an androgen receptor antagonist that blocks the effect of androgens produced by the adrenal gland.
References in periodicals archive ?
Significant adverse events were similar between the intermittent androgen suppression and continuous androgen deprivation patients, including erectile dysfunction (86% vs.
8 years with intermittent androgen suppression, although a stratified log-rank analysis favored the intermittent arm (P = .
There were 9% more prostate cancer deaths on intermittent androgen suppression and 8% more non-prostate cancer deaths on continuous androgen deprivation.
Androgen suppression and radiation vs radiation alone for prostate cancer: A randomized trial.
Lifestyle intervention in men with advanced prostate cancer receiving androgen suppression therapy: a feasibility study.
However, variations in the duration of androgen suppression were not correlated to testosterone levels and were controlled for in the multivariable analysis.
7 demonstrating the non-inferiority of intermittent as opposed to continuous androgen suppression therapy were presented at ASCO and recognized as one of the less that 1% of all abstracts categorized as "the Best of ASCO.
A phase III randomized trial of intermittent versus continuous androgen suppression for PSA progression after radical therapy (NCIC CTG PR.
Luteinizing hormone releasing-hormone agonists (LHRH-A) are widely used as androgen suppression therapy (AST) for localized and metastatic prostate cancer.
Androgen suppression therapy has also been linked to long-term effects, such as diabetes mellitus and cardiovascular disease.

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