androgen insensitivity syndrome


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Related to androgen insensitivity syndrome: testicular feminization syndrome

androgen

 [an´dro-jen]
any steroid hormone that promotes male secondary sex characters. The two main androgens are androsterone and testosterone. Called also androgenic hormone. adj., adj androgen´ic. 

The androgenic hormones are internal endocrine secretions circulating in the bloodstream and manufactured mainly by the testes under stimulation from the pituitary gland. To a lesser extent, androgens are produced by the adrenal glands in both sexes, as well as by the ovaries in women. Thus women normally have a small percentage of male hormones, in the same way that men's bodies contain some female sex hormones, the estrogens. Male secondary sex characters include growth of the beard and deepening of the voice at puberty. Androgens also stimulate the growth of muscle and bones throughout the body and thus account in part for the greater strength and size of men as compared to women.
androgen insensitivity syndrome complete androgen resistance.

an·dro·gen re·sis·tance syn·dromes

a class of disorders associated with 5α-steroid reductase deficiency, testicular feminization, and related disorders. Compare: steroid 5α-reductase, Reifenstein syndrome, infertile male syndrome, testicular feminization syndrome.

androgen insensitivity syndrome

n.
An inherited condition in which the body cells are completely or partially unable to respond to androgens, resulting, in the complete form, in a person with an XY karyotype developing typical female external genitalia but usually no uterus, a short vagina, and undescended or partially descended testes. People with mild or partial forms are infertile and have a variety of phenotypes.

an·dro·gen re·sis·tance syn·dromes

(an'drŏ-jen rĕ-zis'tăns sin'drōmz)
A class of disorders associated with 5α-steroid reductase deficiency, testicular feminization, and related disorders.
Compare: Reifenstein syndrome, testicular feminization syndrome
Synonym(s): androgen insensitivity syndrome.
References in periodicals archive ?
Melo KF, Mendonca BB, Billerbeck AE, Costa EM, Inacio M, Silva FA, et al.Clinical, hormonal, behavioral, and genetic characteristics of androgen insensitivity syndrome in a Brazilian cohort: five novel mutations in the androgen receptor gene.
CAIS: complete androgen insensitivity syndrome, PAIS: partial androgen insensitivity syndrome, F: female, M: male, NTD: N-terminal domain, DBD: DNA-binding domain, LBD: ligand-binding domain, AIS: androgen insensitivity syndromes Supplemental Table 1.
In Complete Androgen Insensitivity syndrome (CAIS) the complete female appearance at birth usually masks the condition completely and the infants are raised without any doubt as girls.
Hence, a diagnosis of complete androgen insensitivity syndrome with germ cell tumor with retroperitoneal lymph node metastasis was made.
The patients with androgen insensitivity syndrome can present with various phenotypic anomalies having as a common aspect the loss of reproductive characteristics.
The child was diagnosed as androgen insensitivity syndrome. Cases 4, 5 and 6 were diagnosed as True hermaphroditism.
Some physical features of opposite sex are evidenced in Androgen insensitivity syndrome or Congenital Adrenal Hyperplasia.
US National Library of Medicine and the National Institutes of Health Androgen Insensitivity Syndrome
Androgen insensitivity syndrome (AIS) is an X-linked recessive condition resulting in a failure of normal masculinization of the external genitalia in chromosomally 46,XY individuals.
In case of congenital hernias we need to rule out intersex syndromes especially in cases of bilateral inguinal hernias which is usually associate with complete androgen insensitivity syndrome (CAIS) (6).
Partial androgen insensitivity syndrome typically presents with micropenis, perineoscrotal hypospadias, and a bifid scrotum with descending or undescending testes and gynecomastia at puberty It is an X-linked recessive disorder resulting from mutations in androgen receptor (AR) gene.
Abnormal gonads (due to gonadal dysgenesis and androgen insensitivity syndrome) have a high risk of developing a dysgerminoma.

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