Castration (androgen ablation
) results in almost complete involution of the ductal epithelial cell component of the prostate with minimal effect on the stroma, a process fully reversible by testosterone supplementation that regenerates and repopulates ductal prostate with epithelial cells.
He was diagnosed to have prostatic carcinoma three years ago, treated initially with androgen ablation
for 1 year followed by chemoradiation as a part of clinical trial.
Quality of life (QOL) analysis from CHAARTED: Chemohormonal androgen ablation
randomized trial in prostate cancer (E3805).
therapy are generally known as the first line of treatment and thus expected to hold maximum revenue share in overall hormone sensitive prostate cancer treatment market.
The localized disease often responds to conventional therapies like androgen ablation
via castration and/or administration of chemical inhibitors but advanced disease resistant to any curative therapies is still challenge for investigators.
(6) Androgen ablation
therapy is frequently used in prostate cancer management because it has been shown that a significant reduction in serum testosterone levels results in regression of advanced prostate cancer.
Kojima et al., "Heat shock protein 27 increases after androgen ablation
and plays a cytoprotective role in hormone-refractory prostate cancer," Cancer Research, vol.
Additional drugs can be used to achieve complete androgen ablation
by blocking androgen production.
For more advanced cancers that have either recurred or metastasized, the gold standard treatment is androgen ablation
We (5) have recently reported a direct analysis of the expression of the TMPRSS2:ERG fusion gene in surgical samples from a total of 84 patients, 24 of whom had received presurgery androgen ablation
However, in 2007, the mainstay of treatment for advanced PCA remains androgen ablation
therapy as originally introduced in the early 1940s.
For decades, androgen ablation
has remained the frontline treatment for CaP that is no longer organ-confined and thus deemed surgically inoperable.