anastellin

A fragment of type-III fibronectin that acts as an antiangiogenic peptide, suppressing tumour growth and metastasis. It blocks serum-dependent proliferation of microvessel endothelial cells (MVEC) by affecting extracellular signal-regulated kinase (ERK)-dependent G1-S transition, inhibiting the Ras/ERK pathway. It binds fibronectin and induces fibril formation, resulting in a fibronectin polymer (superfibronectin), which exhibits enhanced adhesive properties. Together, anastellin and superfibronectin inhibit tumour growth, angiogenesis and metastasis; anastellin activates p38 MAPK and inhibits lysophospholipid signalling.

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Bovine serum albumin, human plasma fibronectin, and its proteolytic fragments, including the III1-C polypeptide (anastellin), guinea pig liver tissue transglutaminase (tTG), human fibrinogen, gelatin, pooled normal rabbit serum, were purchased from Sigma.

As seen in Figure 1(a), overlay of dot-blotted proteins with radioactive MGP demonstrates that MGP binds to fibronectin and fibronectin fragment III1-C (Anastellin).

The current study shows that MGP binds to a region of fibronectin made up by its first type III repeat called III1-C or anastellin [40].

Matrix Gla protein binds to fibronectin and enhances cell attachment and spreading on fibronectin

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