One of the peripheral smears showed atypical plasma cells along with bizarre and multinucleated cells in the bone marrow aspirate and was diagnosed as anaplastic myeloma (Figure 1].
In the present study, there was a case of anaplastic myeloma which showed extramedullary involvement.
In the gastrointestinal tract, the diagnosis of plasmacytoma or myeloma with extramedullary involvement should be made after excluding the more common involvement of non-Hodgkin lymphoma with plasmacytic differentiation specially extranodal marginal zone lymphoma of mucosa associated lymphoid tissues (MALT lymphoma) and lymphoplasmacytic lymphoma (LPL) in cases with bland appearance and plasmablastic lymphoma in case of anaplastic myeloma
. MALT lymphoma and LPL usually show a mixture of CD20 positive lymphocytes and CD138 positive plasma cells, while myeloma shows only plasma cells.