At 1.5 Tesla, mean ADC value for typical meningioma was 1.05+-0.11x10-3 and atypical/
anaplastic meningioma was 0.70 +- 0.04x10-3.
The diagnosis of
anaplastic meningioma involving the spinal cord with extra neural metastasis of the present study was obtained through the clinical, histopathological and IHC findings.
KLF4 is a tumor suppressor in
anaplastic meningioma stem-like cells and human meningiomas.
In our series, 2 men and 2 women (4 patients, 14.81%) were proved to have malignant transformation to
anaplastic meningioma from atypical meningioma during the following operations to their recurrent disease.
Ramzan, "Intraparenchymal
anaplastic meningioma in a child: a rare entity," Asian Journal ofNeurosurgery, vol.
Out of 10 malignant glial tumours 5 cases (50%) were reported as glioblastoma, 4 cases (40%) were reported as high grade astrocytoma and in one case suspicion of
anaplastic meningioma was offered which was confirmed on paraffin section.
Classic, atypical, and
anaplastic meningioma: three histopathological subtypes of clinical relevance.
Twenty-seven cases of WHO grade I meningiomas would have increased in grade to atypical meningiomas (WHO grade II), and one atypical meningioma would have increased to
anaplastic meningioma (WHO grade III).
Ki-67 proliferative index predicts clinical outcomes in patients with atypical or
anaplastic meningioma. Neuropathology, 27(2), 114-120.
There were not any features suggestive of atypical or
anaplastic meningioma such as nuclear pleomorphism, increased mitosis, atypical mitosis or necrosis.
One case diagnosed as glioblastoma multiforme as it showed strong reactivity for GFAP, vimentin and negative for EMA, which ruled out possibility of
anaplastic meningioma. Sarcoma is easily confused with glioblastoma on H&E staining, but GFAP reveals the glioblastoma.
The aggressive clinical course and short survival are consistent with both
anaplastic meningioma and a high-grade sarcoma.