At 1.5 Tesla, mean ADC value for typical meningioma was 1.05+-0.11x10-3 and atypical/ anaplastic meningioma
was 0.70 +- 0.04x10-3.
The diagnosis of anaplastic meningioma
involving the spinal cord with extra neural metastasis of the present study was obtained through the clinical, histopathological and IHC findings.
KLF4 is a tumor suppressor in anaplastic meningioma
stem-like cells and human meningiomas.
In our series, 2 men and 2 women (4 patients, 14.81%) were proved to have malignant transformation to anaplastic meningioma
from atypical meningioma during the following operations to their recurrent disease.
Ramzan, "Intraparenchymal anaplastic meningioma
in a child: a rare entity," Asian Journal ofNeurosurgery, vol.
Out of 10 malignant glial tumours 5 cases (50%) were reported as glioblastoma, 4 cases (40%) were reported as high grade astrocytoma and in one case suspicion of anaplastic meningioma
was offered which was confirmed on paraffin section.
Classic, atypical, and anaplastic meningioma
: three histopathological subtypes of clinical relevance.
Twenty-seven cases of WHO grade I meningiomas would have increased in grade to atypical meningiomas (WHO grade II), and one atypical meningioma would have increased to anaplastic meningioma
(WHO grade III).
Ki-67 proliferative index predicts clinical outcomes in patients with atypical or anaplastic meningioma
. Neuropathology, 27(2), 114-120.
There were not any features suggestive of atypical or anaplastic meningioma
such as nuclear pleomorphism, increased mitosis, atypical mitosis or necrosis.
One case diagnosed as glioblastoma multiforme as it showed strong reactivity for GFAP, vimentin and negative for EMA, which ruled out possibility of anaplastic meningioma
. Sarcoma is easily confused with glioblastoma on H&E staining, but GFAP reveals the glioblastoma.
The aggressive clinical course and short survival are consistent with both anaplastic meningioma
and a high-grade sarcoma.