ALK

(redirected from anaplastic lymphoma receptor tyrosine kinase)

ALK

Abbreviation for:
activin-like kinase
anaplastic lymphoma kinase, see there

Genetics
A gene on 2p23 that encodes an orphan receptor with tyrosine kinase activity belonging to the insulin receptor superfamily, which plays an important role in brain development.

Molecular pathology
ALK is amplified, mutated and rearranged in various cancers, including anaplastic large cell lymphomas, neuroblastoma and non-small cell lung cancer. The most common genetic alterations seen in ALK malfunction are chromosomal rearrangements resulting in multiple fusion genes, including ALK/EML4, ALK/RANBP2 and ALK/ATIC (all on chromosome 2); ALK/TFG (on chromosome 3); ALK/NPM1 and ALK/SQSTM1 (both on chromosome 5); ALK/KIF5B (on chromosome 10); ALK/CLTC (on chromosome 17); ALK/TPM4 (on chromosome 19); and ALK/MSN (on X chromosome).
References in periodicals archive ?
Treatment is currently predominately based on histology and molecular characterisations, with non-squamous patients having greater access to therapy, while patients with epidermal growth factor receptor or anaplastic lymphoma receptor tyrosine kinase mutations have access to premium targeted therapies.
Recent guidelines from International Association for the Study of Lung Cancer/Association for Molecular Pathology/College of American Pathologists recommend at minimum EGFR and anaplastic lymphoma receptor tyrosine kinase (ALK) testing on all tumors with adenocarcinoma histology (including adenosquamous, adeno--small cell neuroendocrine, and poorly differentiated) (1).