anaplastic large cell lymphoma


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an·a·plas·tic large cell lym·pho·ma

a form of lymphoma characterized by anaplasia of cells, sinusoidal growth, and immunoreactivity with CD30 (Ki-1 or Ber-H2).
Synonym(s): Ki-1+ lymphoma

anaplastic large cell lymphoma

A primary non-B cell non-Hodgkin lymphoma, usually of T cell lineage, which is immunoreactive for CD30 and often ALK (anaplastic lymphoma kinase) and characterised by scattered to abundant “hallmark cells”—medium-sized cells with abundant cytoplasm and kidney-shaped nucleus, which tend to aggregate around blood vessels. ALCLs arise either as a primary neoplasm in a node or lymphoid tissue, soft tissue, lung, or skin, or secondary to the transformation of a lymphoproliferative disorder (e.g., mycosis fungoides), T-cell lymphoma, lymphomatoid papulosis or Hodgkin lymphoma.
DiffDx Classical Hodgkin lymphoma.
Clinical findings Often a late-presenting lymphoma with “B symptoms” including night sweating and weight loss.
Molecular >90% have rearrangement of T cell receptor, chromosomal translocation involving the nucleophosmin gene on chromosome 5.
Management CHOP, radiation for bulky disease.

anaplastic large cell lymphoma

Abbreviation: ALCL
A rare form of non-Hodgkin, T-cell lymphoma that may behave indolently when limited to the skin or may be more aggressive and spread to lymph nodes throughout the body.
See also: lymphoma
References in periodicals archive ?
Kim et al., "Primary anaplastic large cell lymphoma of the lung presenting with acute atelectasis," Thoracic Cancer, vol.
Lee, "Silicone implant and primary breast ALK1-negative anaplastic large cell lymphoma, fact or fiction?" International Journal of Clinical and Experimental Pathology, vol.
Conclusion: Anaplastic large cell lymphoma is more common in males and young adults.
Differential diagnosis and treatment of primary, cutaneous, anaplastic large cell lymphoma - not always an easy task.
In the survival analysis by PTCL subtype, PTCL-unspecified (PTCL-U) cases had the longest median survival at 9 months, followed by anaplastic large cell lymphoma (ALCL) at 6 months and primary CNS lymphoma (PCNSL) at 2.5 months.
Treatment with SGN-35 resulted in complete tumor regressions in preclinical models of Hodgkin's disease and anaplastic large cell lymphoma (ALCL).
A biopsy of the lesion demonstrated an anaplastic large cell lymphoma (ALCL).
Ki-l-positive anaplastic large cell lymphoma of the masticator space with intracranial extension.
Health Canada has completed an update to a 2017 safety review on breast implant-associated anaplastic large cell lymphoma, BIA-ALCL, and has found that the rate of BIA-ALCL in Canada is significantly higher in patients with macro-textured breast implants compared to other implants.