Isolated extracranial recurrence of anaplastic ependymoma
. Pediatr Blood Cancer 2011; 56(2):317-318.
Tim died Tuesday from recent complications of a brain and spinal cancer called anaplastic ependymoma
, which he was diagnosed with at age 4.
They are considered WHO grade II unless anaplasia, increased mitotic activity endothelial proliferations, and/or necrosis are present (Figure 4, C), in which case a diagnosis of anaplastic ependymoma
, WHO grade III, is rendered, although clinical behavior is not well predicted by grade.
The immediate impression was anaplastic ependymoma
. Nevertheless, to our surprise, there were also some other regions displaying an entirely different morphology, and which composed approximately 50% of the sample, featuring cells with a large optically clear vacuole pushing the nucleus to the periphery resembling either mature adipose tissue or signet-ring cells (Figures 2(a) and 2(b)).
Doctors discovered eight-year-old Liam had the aggressive tumour, called an anaplastic ependymoma
, after he was knocked down by a car on the way home from school in January.
It's for three-year-old Caoimhe Neeson, who has anaplastic ependymoma
with spinal metastases, a grade three malignant brain tumour.
Despite surgery followed by chemotherapy the aggressive tumour, called an anaplastic ependymoma
, returned and Thomas had to go through a second brain operation three weeks ago.
Within three months the aggressive tumour, called an anaplastic ependymoma
, returned and Thomas had to go through a second brain operation three weeks ago to remove the cancer.
Neoplastic lesions included various grades and types of astrocytoma [35; 57.37%] metastatic lesions [6; 9.84%] lymphoma [5; 8.19%] meningioma [7; 11.47%] medulloblastoma [2; 3.27%] acoustic neuroma [2; 3.27%] anaplastic ependymoma
[2; 3.27%] Primitive Neuroectodermal tumour (PNET ) [1; 1.63%] and haemangioblastoma [1; 1.63%].
Other diagnoses made by the central reviewers included CNS germ cell tumor, choroid plexus carcinoma, anaplastic ependymoma
, and malignant meningioma, all of which reflect the epithelial and occasionally papillary appearances manifested by the tumor.
The term 'glioma' includes all the tumours arises from glial cells, including grades I, pilocytic astrocytomas, pleomorphic xanthoastrocytomas, and subependymal giant cell astrocytomas, grade II oligodendrogliomas and astrocytomas, grade III anaplastic oligodendrogliomas, anaplastic astrocytomas, anaplastic oligoastrocytomas, anaplastic ependymomas
and grade IV glioblastoma multiform (GBM).1