Patient was 22 year old female diagnosed as a case of
Anaplastic cell carcinoma thyroid.
Foucar et al also reported 2 similar cases of anaplastic myeloma with extramedullary involvement showing primitive appearing
anaplastic cells both in bone marrow and in extramedullary site.
Angiosarcoma is an uncommon malignant neoplasm characterized by rapidly proliferating, extensively infiltrating
anaplastic cells derived from blood vessels and lining irregular blood-filled spaces.
Diseased mussels showed heavy levels of
anaplastic cells infiltration on the connective tissue, particularly in the subepithelial regions.
Review at CUH of H&E-stained slides from the low-grade lymphoma of patient 2 revealed a lymph node replaced by a population of small- to medium-sized centrocytes in a vaguely nodular pattern (Figure, C) without a significant population of large, irregular centroblasts or
anaplastic cells.
Variable amount of connective tissue with fatty
anaplastic cells was also found (Fig 2).
Histopathology shows small
anaplastic cells with mi- totic activity and rosette formation.
According to histology, mussels showed a continuum of disease progression, from early stages with a few
anaplastic cells around the stomach epithelium to more advanced cases with multiple foci of neoplastic cells in the tissues, finally to terminal cases with profuse infiltration of neoplastic cells in all tissues.
Section of the endobronchial biopsy (Figure 3) examined in our institution and reviewed by AFIP (Armed Forces Institute of Pathology), demonstrated a dense proliferation of discohesive
anaplastic cells with enlarged round to pleomorphic nuclei with abundant cytoplasm.
A photomicrograph of the tumor shows storiform-pleomorphic pattern with
anaplastic cells arranged haphazardly (Figure 4).
They are
anaplastic cells that grow into nerve cells.
6,13,14) The
anaplastic cells characteristically show strong and uniform membranous expression of CD30.
