Widespread, variably intense [Beta]III staining was present in the cytoplasm of overt astroglial phenotypes with multipolar fibrillary processes (Figure 2, a through f), in large "ganglioid" astroglial cells with prominent nucleoli and fibrillary cell processes (Figure 2, f), and in small
anaplastic cells resembling "primitive" glioblasts (Figure 2, g).
Anaplastic cells may occasionally resemble the Reed-Sternberg cells found in classical Hodgkin lymphoma.
According to histology, mussels showed a continuum of disease progression, from early stages with a few
anaplastic cells around the stomach epithelium to more advanced cases with multiple foci of neoplastic cells in the tissues, finally to terminal cases with profuse infiltration of neoplastic cells in all tissues.
A photomicrograph of the tumor shows storiform-pleomorphic pattern with
anaplastic cells arranged haphazardly (Figure 4).
They are
anaplastic cells that grow into nerve cells.
Tumors with features of both large cells and severe
anaplastic cells often occur together, lending the group the name "large cell/anaplastic.
Primary cutaneous ALCL is a CD4+ T-cell tumor composed of cohesive large
anaplastic cells, with indented to slightly irregular nuclei and abundant pink cytoplasm, that are similar to those observed in systemic ALCL (Figure 5, A and B).
With further study, it became apparent that these
anaplastic cells had the cytologic and immunohistochemical characteristics of megakaryocytes.
The nucleus, nucleolus, and cytoplasm of the large
anaplastic cells stained blue.
