anaplastic carcinoma

an·a·plas·tic car·ci·no·ma

carcinoma with an absence of epithelial structural differentiation.

anaplastic carcinoma

An aggressive epithelial malignancy which lacks histologic criteria required to confirm its embryonic lineage. Anaplastic carcinomas often respond poorly to excision, chemotherapy and radiotherapy. They generally lack architectural landmarks and are divided into small cell, intermediate cell, giant cell, spindle cell and mixed cell types, and occur in the lungs, thyroid, oesophagus and elsewhere.
 
Prognosis
Generally poor; 6-month survival is the norm.
 
Aetiology
Unknown; possibly linked to radiation exposure.
References in periodicals archive ?
Malignant tumours encountered other than thymic carcinomas and Lymphomas were Synovial Sarcoma, Malignant spindle cell lesion, Malignant Fibrous histiocytic tumour (MFH) one each, three cases of Metastatic carcinoma deposits of Unknown primary, and three cases of metastatic lymph node deposits in mediastinum of Non-small cell lung carcinoma (NSCLS), Adeno Carcinoma, Anaplastic Carcinoma.
Anaplastic carcinoma of the pancreas arising in an intraductal papillary mucinous neoplasm: A case report.
Additional types of thyroid cancer include medullary thyroid carcinoma, anaplastic carcinoma, thyroid lymphoma, and thyroid sarcoma.
Malignant mural nodules may include anaplastic carcinoma, clear cell carcinoma, neuroendocrine carcinoma, giant cell carcinoma, carcinosarcoma, and sarcoma (1).
(3) It has also been proposed that LMS may originate as a result of smooth-muscle metaplasia from a previously existing anaplastic carcinoma of the thyroid.
Table 1: Benign and malignant thyroid tumours Pathological diagnosis n = 676 Benign tumours (n = 195) Percent Follicular adenoma 115 59.0% Hurthle cell adenoma 80 41.0% Malignant tumours (n = 481) Papillary carcinoma 298 62.0% Follicular carcinoma 82 17% Medullary carcinoma 40 8.3% Hurthle cell carcinoma 27 5.6% Anaplastic carcinoma 15 3.1% Lymphoma 6 1.3% Metastatic carcinoma 8 1.7% unspecified carcinoma 3 0.6% Malignant teratoma of thyroid 1 0.2% Malignant solitary fibrous tumour 1 0.2% Table 2: Characteristics of patients who had HCNs (n = 107) Parameter Hurthle cell Hurthle cell p-value carcinoma adenoma No.
The histological types of cancer observed in patients with choledochal cyst are as follows: adenocarcinoma (73% to 84% of cases), anaplastic carcinoma (10% of cases), undifferentiated carcinoma (5% to 7% of cases), squamous cell carcinoma (5% of cases), and other cancers (1.5% of cases) [2, 4].
In the article titled "Amiodarone Induced Hyponatremia Masquerading as Syndrome of Inappropriate Antidiuretic Hormone Secretion by Anaplastic Carcinoma of Prostate" [1], the discussion section was similar to that of Pham et al.
PDTC, earlier known as insular carcinoma, is considered to have intermediate prognostic implication (between well differentiated and anaplastic carcinoma) [8,9].
The final pathology report confirmed undifferentiated anaplastic carcinoma (8.7 cm) involving the left thyroid, positive for lymphatic involvement (2/5 central nodes) and extrathyroidal extension to the pretracheal cartilage.
However, no case of medullary or anaplastic carcinoma was diagnosed in our study (Fig.1).
[8] interpreted that the most common group was SCC (93.3%) followed by anaplastic carcinoma.