anaplastic Wilms tumour
anaplastic Wilms tumourA histopathologically defined variant of Wilms tumour, which must have all of the following criteria:
• Nuclei at least three-fold greater than adjacent nuclei of same histogenesis;
• Nuclear hyperchromasia;
• Enlarged or multipolar mitoses.
Anaplasia in children with Wilms’ tumour signals a poor prognosis and chemoresistance.