Endocannabinoid 2-arachidonyl glycerol is a full agonist through human type 2 cannabinoid receptor: antagonism by anandamide
The report provides comprehensive information on the Fatty Acid Amide Hydrolase (FAAH or Anandamide
Amidohydrolase or EC 3.
The reduction in metabolism increases 2-AG and anandamide
concentrations, which modulates neurotransmitter release and restores endogenous stimulation of endocannabinoid receptors.
Moreover, the endocannabinoid anandamide
is also involved in neurodegeneration and thus acylethanolamines, and especially palmitoylethanolamine, appear to play an important role as neuroprotectors.
and its congeners inhibit human plasma butyrylcholinesterase.
Amides and its derivatives are an important functionality in both natural and synthetic bioactive compounds such as niacin amide is vitamin B  fatty acid amides, anandamide
is analgesic  oleamide that is present in cerebrospinal fluid induces sleep  while erucamide stimulates formation of new blood vessels  and a natural painkiller found in brain peptide is enkephalins .
Dietary linoleic acid elevates the endocannabinoids 2-AG and anandamide
and promotes weight gain in mice fed a low fat diet.
(N-arachidonoylethanolamine), the first-discovered endocannabinoid in humans (Devane et al.
20,21,38) Also, CBD is thought to inhibit the degradation of the endocannabinoid anandamide
(38) and may interfere with THC metabolism.
Finally, other investigators identified a third type of LTD in the BNST that was dependent on mGluR5-mediated generation of the lipid signal anandamide
, which then acted on postsynaptic transient receptor potential V1 (TRPV1) channels (Puente et al.
It has been reported that endogeneous cannabinoids including anandamide
show negative inotropic and antiarythmical action by way of voltage-gated sodium channels and L-type calcium channels independent of sympathetic activity.
2006) The endocannabinoid anandamide
protects neurons during CNS inflammation by induction of MKP-1 in microglial cells.