Dietary linoleic acid elevates endogenous 2-AG and anandamide
and induces obesity.
Effects of anandamide
on potassium channels in rat ventricular myocytes: a suppression of 1(to) and augmentation of K(ATP) channels.
Formation and inactivation of endogenous cannabinoid anandamide
in central neurons.
One of the primary cannabinoids is anandamide
, derived from the Sanskrit word meaning bliss.
Another similarity with the opioid system is the existence of endogenous cannabinoid receptor agonists, the most studied of which is anandamide
Cannabinoids, like anandamide
, were tried successfully to reduce testicular IR injury (11).
Subtypes, coding gene, activators and inhibitors of 4TM family of potassium channels 4TM family Subtypes Coding gene TWIK TWIK1, KCNK1 TWIK2, KCNK6 TWIK3 KCNK7 TREK TREK1, TREK2, TRAAK KCNK2 KCNK10 KCNK4 TASK TASK1, KCNK3 TASK3,TASKS KCNK9 KCNK15 TALK TALK1, TASK2, TASK4 KCNK16 KCNK5 KCNK17 THIK THIK1, THIK2 KCNK13 KCNK12 TRESK TRESK1 KCNK18 4TM family Activators Inhibitors TWIK Acid pH -- TREK Halothane, riluzole, heat, arachidonic acid, acid pH -- TASK Halothane, alkaline pH Anandamide
TALK Alkaline pH -- THIK -- Halothane TRESK -- Arachidonic acid Source: Refs 6, 7 Table: III.
9]-tetrahydrocannabinol and anandamide
antinociception in nonarthritic and arthritic rats.
Chronic ethanol increases the cannabinoid receptor agonist anandamide
and its precursor N-arachidonoylphos-phatidylethanolamine in SK-N-SH cells.
In contrast, anandamide
binds strongly to CB 1 (as strongly as THC from cannabis), whereas the Echinacea alkylamides only have a weak affinity for CB1 receptors (but perhaps sufficient to promote the sense of well-being that many patients report after taking Echinacea consistently).
Previous studies in other tissues have shown that anandamide
, an endogenous agonist of TRPV1, can induce vasodilation [Davis et al.
He describes chocolate as "an addicting drug, targeting the same spot in your brain as opiate drugs" and points out it contains caffeine, theobromine, phenylethylamine and anandamide