anandamide

an·an·da·mide

(an-an'dă-mīd),

N-arachidonoylethanolamine, a brain lipid that binds to cannabinoid receptors; also found in cocoa.

anandamide

(ə-năn′də-mīd′)

A neurotransmitter, C₂₂H₃₇NO₂, found especially in the brain, that binds to the same receptors as cannabinoids and influences mood, appetite, motivation, perception of pain and pleasure, and memory. Anandamide is also found in small amounts in cocoa and chocolate.

anandamide

(ă-nan′dă-mīd″) [Sanskrit ananda, endlessness, eternal bliss + amide]

A neurotransmitter that binds to and activates cannabinoid receptors on brain cells.

Mentioned in ?

endocannabinoid-signalling pathway

References in periodicals archive ?

Endocannabinoid 2-arachidonyl glycerol is a full agonist through human type 2 cannabinoid receptor: antagonism by anandamide.

The endocannabinoid system in pain and inflammation: Its relevance to rheumatic disease

The report provides comprehensive information on the Fatty Acid Amide Hydrolase (FAAH or Anandamide Amidohydrolase or EC 3.

Fatty Acid Amide Hydrolase (FAAH or Anandamide Amidohydrolase or EC 3.5.1.99) - New Market Report

The reduction in metabolism increases 2-AG and anandamide concentrations, which modulates neurotransmitter release and restores endogenous stimulation of endocannabinoid receptors.

Zynerba Pharmaceuticals awarded orphan drug designation for ZYN002 for Fragile X Syndrome

Moreover, the endocannabinoid anandamide is also involved in neurodegeneration and thus acylethanolamines, and especially palmitoylethanolamine, appear to play an important role as neuroprotectors.

Lipids and Oxidative Stress Associated with Ethanol-Induced Neurological Damage

Anandamide and its congeners inhibit human plasma butyrylcholinesterase.

Purification and Anticholinesterase Sensitivity of Cholinesterase Extracted from Liver Tissue of Puntius Javanicus

Amides and its derivatives are an important functionality in both natural and synthetic bioactive compounds such as niacin amide is vitamin B [1] fatty acid amides, anandamide is analgesic [2] oleamide that is present in cerebrospinal fluid induces sleep [3] while erucamide stimulates formation of new blood vessels [4] and a natural painkiller found in brain peptide is enkephalins [5].

Synthesis, Antimicrobial, Antioxidant and Nematicidal Activity of (2E,4E)-5-(Benzo[d] [1,3]dioxol-5yl)penta-2,4-dienamides

Dietary linoleic acid elevates the endocannabinoids 2-AG and anandamide and promotes weight gain in mice fed a low fat diet.

The key to healthy weight: good fat in, excess fat out: to address the obesity epidemic effectively it is critical to target causes, not just risk factors

Anandamide (N-arachidonoylethanolamine), the first-discovered endocannabinoid in humans (Devane et al.

Evolution and classification of Cannabis sativa (marijuana, hemp) in relation to human utilization

20,21,38) Also, CBD is thought to inhibit the degradation of the endocannabinoid anandamide (38) and may interfere with THC metabolism.

Cannabis-derived pharmaceuticals

Finally, other investigators identified a third type of LTD in the BNST that was dependent on mGluR5-mediated generation of the lipid signal anandamide, which then acted on postsynaptic transient receptor potential V1 (TRPV1) channels (Puente et al.

Mechanisms of neuroplasticity and ethanol's effects on plasticity in the striatum and bed nucleus of the stria terminalis

It has been reported that endogeneous cannabinoids including anandamide show negative inotropic and antiarythmical action by way of voltage-gated sodium channels and L-type calcium channels independent of sympathetic activity.

Cardiovascular side effects related with use of synthetic cannabinoids "bonzai": two case reports

2006) The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells.