analytic sensitivity

an·a·lyt·i·c sen·si·tiv·i·ty

1. the threshold of detection;
2. the degree of response to a change in concentration of analyte being measured in an assay.
Farlex Partner Medical Dictionary © Farlex 2012

analytical sensitivity

The concentration at which the mean response is statistically beyond the noise limits of the signal at zero concentration. Analytical sensitivity is the ability of a test to detect a target analyte (e.g., an antibody or antigen), which is usually expressed as the minimum detectable concentration of the analyte. In practice, the way in which analytic sensitivity is calculated varies according to the lab, with differing replicates and matrices.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

an·a·lyt·i·c sen·si·ti·vi·ty

(an'a-lit'ik sen'si-tiv'i-tē)
The ability of a test to detect a particular analyte or substance or a minimal change in the concentration of the substance.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
The advantage of Sanger sequencing is the ability to detect any mutation within the PCR amplification product without prior knowledge of the location or the type of mutation; however, Sanger sequencing is limited by a low analytic sensitivity of 15% to 20%, which limits its ability to analyze samples with low tumor cellularity.
(24) Leishmania genus and LVL assay optimization, limit of detection (LoD), analytic sensitivity, and specificity test results are previously described.
There are 2 major benefits to the T2Candida Panel, they write: first, "the rapid turnover time allowing a same day result for most samples, whereas blood culture often requires two days of incubation or even longer before Candida is detected"; and second, it has "a high analytic sensitivity for the species included."
Data regarding analytic sensitivity and specificity were obtained from the Food and Drug Administration submission file for the LFA.
As soon as serum samples were obtained, serum total free [E.sub.2] (analytic sensitivity: 0.5 ng/ml, within-run precision CV:3.3%), total T (analytic sensitivity: 0.02 ng/ml, within-run precision CV:2.7%), follicle-stimulating hormone (FSH) (analytic sensitivity: 0.1mIU/ml, within-run precision CV:2.6%) and luteinizing hormone (LH) (analytic sensitivity: 0.1 mIU/ml, within-run precision CV:1.2%)levels were determined with electrochemiluminescence immunoassay (Modular Analytics E170, Roche Diagnostic, Manheim, Germany).
The analytic sensitivity of the method was then tested to determine the lowest measurable concentration of the toxin.
From the October 1989 survey to the July 1990 survey, overall EIA analytic sensitivity declined from 99.4% to 96.7% (Table 3).
While multiplexed analysis of lung cancers by next-generation sequencing (NGS) in place of single-analyte testing may be advised from an analytic sensitivity and tissue preservation perspective, the economics will make adoption more challenging.
Advances in immunoassay technologies and the international adoption of traceable troponin calibration standards have resulted in development of troponin assays with unprecedented analytic sensitivity and precision.
The 6 parameters were (a) the mean number of reads mapped to ExQC DNA, (b) the mean number of sample reads normalized to the mean number of reads of ExQC DNA, (c) the correlation coefficient of the expected vs observed values of ExQC DNA heteroplasmy, (d) the ratio of the SD of the mean number of reads to the mean number of reads mapped to sample DNA, (e) the analytic specificity, and (f) the analytic sensitivity of a run determined from the reads mapped to mtDNA.
Performance is described in terms of analytic sensitivity, analytic specificity, and overall analytic performance.
Included in this gap is the absence of a simple direct measure of analytic sensitivity, that is, analytic response curves and limits of detection (LODs).