anal intraepithelial neoplasia


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia.

anal intraepithelial neoplasia

A carcinoma in situ of the anorectal mucosa that is embryologically, histologically, and pathologically analogous to cervical intraepithelial neoplasia, which is linked to HPV infection and divided into low-grade (LG-AIN) and high-grade (HG-AIN) tumours, the latter of which is associated with aggressive squamous cell carcinoma.

Risk factors
Anal HPV infections, receptive anal intercourse, HIV infection and decreased CD4-+ve T cells.
 
HPV types
6/11, 31/33/35 and 16/18.

anal intraepithelial neoplasia

Abbreviation: AIN
A precancerous change in the squamous cells of the anus that may eventually develop into anorectal cancer. It is similar to cervical intraepithelial neoplasia in that it is a premalignant lesion that arises in squamous cells, is found primarily in sexually active people, and is associated with human papillomavirus and HIV.
Synonym: anal dysplasia; anal squamous intraepithelial lesion
See also: neoplasia
Mentioned in ?
References in periodicals archive ?
Efficacy of trichloroacetic acid in the treatment of anal intraepithelial neoplasia in HIV-positive and HIV-negative men who have sex with men.
Summary of studies focused on effectiveness of different treatment modalities of anal intraepithelial neoplasia (AIN).
Anal cancer screening knowledge, attitudes, and experiences among men who have sex with men in Ottawa, Ontario
High resolution anoscopy findings for men who have sex with men: inaccuracy of anal cytology as a predictor of histologic high-grade anal intraepithelial neoplasia and the impact of HIV serostatus.
Self-collected versus clinician-collected anal cytology specimens to diagnose anal intraepithelial neoplasia in HIV-positive men.
Anal cancer screening approach awaits more data and clinical expertise
The vaccine was 73% efficacious against anal intraepithelial neoplasia of grade 1, including condyloma, and 74.
In the intention-to-treat population, vaccine efficacy against anal intraepithelial neoplasia related to any of the four HPV types was 50.
HPV vaccine protected against anal neoplasia in gay men
HRA sensitivity in detecting anal intraepithelial neoplasia among different high-risk populations has been demonstrated to be about 69 to 93%, with a specificity ranging from 32 to 64%.
HPV infection and intraepithelial lesions from the anal region: how to diagnose?
High-grade anal intraepithelial neoplasia among HIV-1-infected men screening for a multicenter clinical trial of a human papillomavirus vaccine.
HPV vaccination for people with HIV--who, when, why?
Conventionally, lesions involving the former have been termed dysplasia, in situ carcinoma, or anal intraepithelial neoplasia, whereas lesions involving the skin, Bowen disease.
An update on tumors of the anal canal
Clinical spectrum and virologic characteristics of anal intraepithelial neoplasia in HIV infection.
Diagnostic methods for prevention of anal cancer and characteristics of anal lesions caused by HPV in men with HIV/AIDS
GARDASIL is not intended to be used for treatment of active external genital lesions; cervical, vulvar, vaginal, and anal cancers; cervical intraepithelial neoplasia, vulvar intraepithelial neoplasia, vaginal intraepithelial neoplasia, or anal intraepithelial neoplasia.
New England Journal of Medicine Publishes Efficacy and Safety Data for GARDASIL[R] in Males
Food and Drug Administration (FDA) has approved GARDASIL([R]) [Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) Vaccine, Recombinant] for the prevention of anal cancer caused by human papillomavirus (HPV) types 16 and 18 and for the prevention of anal intraepithelial neoplasia (AIN) grades 1, 2 and 3 (anal dysplasias and precancerous lesions) caused by HPV types 6, 11, 16 and 18, in males and females 9 through 26 years of age.
US FDA Approves New Indication for Merck's HPV Vaccine, GARDASIL[R]

Medical browser ?
Full browser ?