anal intraepithelial neoplasia

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anal intraepithelial neoplasia

A carcinoma in situ of the anorectal mucosa that is embryologically, histologically, and pathologically analogous to cervical intraepithelial neoplasia, which is linked to HPV infection and divided into low-grade (LG-AIN) and high-grade (HG-AIN) tumours, the latter of which is associated with aggressive squamous cell carcinoma.

Risk factors
Anal HPV infections, receptive anal intercourse, HIV infection and decreased CD4-+ve T cells.
 
HPV types
6/11, 31/33/35 and 16/18.

anal intraepithelial neoplasia

Abbreviation: AIN
A precancerous change in the squamous cells of the anus that may eventually develop into anorectal cancer. It is similar to cervical intraepithelial neoplasia in that it is a premalignant lesion that arises in squamous cells, is found primarily in sexually active people, and is associated with human papillomavirus and HIV.
Synonym: anal dysplasia; anal squamous intraepithelial lesion
See also: neoplasia
References in periodicals archive ?
Palefsky said he examines for anal dysplasia the same way one does for cervical dysplasia.
Of course HPV infection, the endpoint in these two studies, does not always lead to anal dysplasia, AIN, or cancer.
Screening anal dysplasia in HIV-infected patients: is there an agreement between anal pap smear and high-resolution anoscopy-guided biopsy?
The prevalence, and predictive value, of abnormal anal cytology to diagnose anal dysplasia in a population of HIV-positive men who have sex with men.
Measurement characteristics of anal cytology, histopathology, and high-resolution anoscopic visual impression in an anal dysplasia screening program.
HspE7, the company's lead product candidate, is in a Phase II clinical trial for the treatment of children with recurrent respiratory papillomatosis and a Phase III clinical trial for the treatment of patients with anal dysplasia, a precursor to anal cancer.