aplastic anaemia(redirected from anaemia gravis)
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aplastic anaemiaAnaemia due to a failure in marrow production of RBCs, often accompanied by failure in WBC and platelet production (i.e., granulocytopaenia, thrombocytopaenia).
Toxins (benzene, toluene, insecticides), radiotherapy, drugs (carbamazepine, chemotherapy, chloramphenicol, gold salts, phenytoin, phenylbutazone, quinacrine, sulfonamides, tolbutamide), autoimmunity, SLE, post-hepatitis, pregnancy, paroxysmal nocturnal haemoglobinuria.
Aplastic anaemia is often unresponsive to specific therapy.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
aplastic anaemiaA serious form of anaemia in which no new blood cells are formed in the bone marrow. About 30% of cases follow virus infections, especially MEASLES, MUMPS and HEPATITIS or are induced by drugs such as BUTAZOLIDINE, SULPHONAMIDES, CHLORAMPHENICOL or dipyrone. The condition results from damage to the haemopoietic stem cells often from an autoimmune process that can be checked by immunosuppressive drug treatment. Blood transfusions are often necessary to maintain life.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005