FUS(redirected from amyotrophic lateral sclerosis 6)
Also found in: Encyclopedia.
FUSA gene on chromosome 16p11.2 that encodes a multifunctional protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex, which is involved in pre-mRNA splicing and export of processed mRNA to the cytoplasm. FUS belongs to the FET family of RNA-binding proteins that regulate gene expression, maintain genomic integrity and process mRNA/microRNA processing.
FUS mutations cause amyotrophic lateral sclerosis type 6; a FUS/CHOP translocation (t(12;16)(q13;p11)) leads to the formation of a chimeric protein, which induces liposarcoma.