amyloid precursor protein

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Related to amyloid precursor protein: amyloidosis, Tau protein

amyloid precursor protein

n. Abbr. APP

A protein found in cell membranes that forms beta-amyloid fragments when cleaved by the secretase designated beta.

amyloid precursor protein

Abbreviation: APP

An integral membrane protein concentrated at neuron synapses that is cleaved biochemically into components, one of which is the Alzheimer's disease–associated beta amyloid. Mutations in the gene for APP on chromosome 21 account for less than 5% of early-onset familial Alzheimer's disease.

amyloid precursor protein

A natural brain protein that is coded for on chromosome 21. This protein is related in some way to memory. Point mutations are found in the gene for this protein in people who suffer from a familial form of early-onset ALZHEIMER'S DISEASE. Only a small proportion of cases of Alzheimer's disease, however, are caused in this way. Abnormally folded AMYLOID protein in the form of plaques and tangles occur in brain cells in Alzheimer's disease but also in chronic suppurative states in other parts of the body.

References in periodicals archive ?

A splice variant of [beta]-secretase deficient in the amyloidogenic processing of the amyloid precursor protein. J Biological Chem 2001 ;276( 15): 12019-12023.

Association of G/C (rs638405) Polymorphism in [beta]-secretase Gene with Alzheimer's Disease

MiR-16 regulates cell death in Alzheimer's disease by targeting amyloid precursor protein. Eur Rev Med Pharmacol Sci 2015;19:4020-7.

Effect of Regulatory Network of Exosomes and microRNAs on Neurodegenerative Diseases

DSCAM expression was measured by western blot (A) and qRT-PCR (B) in hippocampal lysates from amyloid precursor protein (APP) transgenic (Tg) and wild-type (WT) mice (1, 3, 6, and 12 months [mo] old).

Hippocampal overexpression of Down syndrome cell adhesion molecule in amyloid precursor protein transgenic mice

The roles of amyloid precursor protein (APP) in neurogenesis, implications to pathogenesis and therapy of Alzheimer disease (AD).

Neurohormetic responses of quercetin and rutin in a cell line over-expressing the amyloid precursor protein (APPswe cells)

Avadhani, "Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells," The Journal of Cell Biology, vol.

Killing Me Softly: Connotations to Unfolded Protein Response and Oxidative Stress in Alzheimer's Disease

From synaptic spines to nuclear signaling: nuclear and synaptic actions of the amyloid precursor protein. J.

Bacterial, viral and fungal infection factors in aetiophathogenesis of Alzheimer's disease

(5) Nonstandard abbreviations: A[beta], [beta]-amyloid; CSF, cerebrospinal fluid; APP, amyloid precursor protein; t-tau, total tau; p-tau, phosphorylated tau; PET, positron emission tomography; PiB, Pittsburgh compound B; ADNI, AD Neuroimaging Initiative; IVD, in vitro diagnostic; RUO, research use only; CRM, certified reference material; RMP, reference measurement procedure; BACE, [beta]-secretase.

Biomarkers, assays, and therapies for Alzheimer disease

The current concept for Alzheimer's disease development involves the cleavage of amyloid precursor protein (APP) to amyloid beta (A[beta]) peptide by BACE1 leading to the preliminary constituent of amyloid plaques in the brains of individuals with the disease [6].

Amino acid sequence and structural comparison of BACE1 and BACE2 using evolutionary trace method

Robakis, "An alternative secretase cleavage produces soluble Alzheimer amyloid precursor protein containing a potentially amyloidogenic sequence, " Journal of Neurochemistry, vol.

The beta-amyloid protein of Alzheimer's disease: communication breakdown by modifying the neuronal cytoskeleton

Huang plotted the circadian secretion patterns of Abeta-40 and Abeta-42, and the amyloid precursor protein (APP).

Sleep problems may increase dementia risk

The Dominantly Inherited Alzheimer's Network (DIAN) study, an international study of inherited forms of AD, is following members of families who have mutations in one of three genes: amyloid precursor protein, presenilin 1, or presenilin 2.

Research on inherited AD may lead to earlier intervention

A broad range of drugs were developed to achieve these objectives including antibodies to A[beta] and inhibitors of enzymes that form A[beta] by metabolizing the precursor protein known as "amyloid precursor protein".