Sandrock: The presence of amyloid plaques
is a pathological hallmark of Alzheimer's disease.
For this study, the team used the tracer molecules PIB, Deprenyl and FDG to study the amount of amyloid plaques
, inflammatory changes in the form of astrocyte activation, astrocytes being the most common type of glial (supporting) cell in the brain.
Researchers in St Louis tested the sleep patterns of 100 people aged 45 to 80, and found that 25% of the participants had evidence of amyloid plaques
, which can appear years before the symptoms of Alzheimer's begin.
The major pathologic findings in the AD brain at autopsy are amyloid plaques
(extracellular), neurofibrillary tangles (intracellular), and the loss of synaptic connections.
It is believed to stop the spread of amyloid plaques
that damage the wiring in the brain and lead to Alzheimer's and other forms of dementia.
Alzheimer's disease (AD) is a complex neurodegenerative disease characterized by abnormal protein deposits - amyloid plaques
(containing the AB1-42 peptide) and neurofibrillary tangles (containing tau protein) - in the brain.
31 ( ANI ): Researchers have said that high levels of "good" cholesterol and low levels of "bad" cholesterol are correlated with lower levels of the amyloid plaque
deposition in the brain - a hallmark of Alzheimer's disease.
Increased levels of beta amyloid plaque
is a defining pathological feature of AD, the most common form of dementia and the sixth leading cause of death in the United States.
On January 20th, an advisory committee of the FDA voted to conditionally recommend approval of Eli Lilly's PET imaging agent Amyvid for detecting beta amyloid plaque
deposits that could be precursors to Alzheimer's disease.
The research, published online July 11, 2012 in the journal Neurology, expands on earlier studies that demonstrate how amyloid plaque
buildup can be used to help predict future cognitive decline.
A total of 18 had a positive scan, indicating amyloid plaque
burden in the brain consistent with pre clinical Alzheimer's disease, Dr.
This tracer is the most advanced compound of its type in development for imaging amyloid plaque
in the brain associated with Alzheimer's disease.