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Amyloid beta-protein fibrillogenesis Structure and biological activity of protofibrillar intermediates.
Isobe I, Yanagisawa K, Michikawa M (2000) A possible model of senile plaques using synthetic amyloid beta-protein and rat glial culture.
They discuss the biochemistry and cell biology of amyloid beta-protein precursor, tau, presenilin, beta-secretase, and apolipoprotein E and their involvement in the disease, as well as its clinical, neuropathological, imaging, and biomarker phenotypes; associated genetic alterations; and epidemiological insights into its cause and pathogenesis.
Previously, researchers found that the presence of the [epsilon]4 allele in the apolipoprotein E (APOE-[epsilon]4) gene is associated with increased deposition of amyloid beta-protein after head injury (Nat.
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